ChemInform Abstract: Regioselective Synthesis of Pyridoquinolones and Pyridocoumarins via Molecular Iodine-Mediated 6-endo-dig Electrophilic Cyclization.
The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.
A synthetic approach to regioselective synthesis of 3-organochalcogenyl spiro[4,5]trienones and 3-organochalcogenyl[4,5]triene-2,6-diones is described through the reaction of arylpropiolamides with an electrophilic chalcogen source.
A mild and efficient protocol for the ipso-iodination of aryl boronic acids using N-iodomorpholinium iodide (NIMI) generated in situ from morpholine and molecular iodine as a novel iodinating agent has been developed.
Regioselective Synthesis of 3-Haloalkyl-isoxazoles from the Electrophilic Cyclization of Halogenated Oximes