ChemInform Abstract: Catalytic Asymmetric Construction of Spirocycles Containing Pyrrolidine Motifs and Spiro Quaternary Stereogenic Centers via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 2-Alkylidine-Cycloketones.

ChemInform ◽  
2011 ◽  
Vol 42 (50) ◽  
pp. no-no
Author(s):  
Tang-Lin Liu ◽  
Zhao-Lin He ◽  
Qing-Hua Li ◽  
Hai-Yan Tao ◽  
Chun-Jiang Wang
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Stereogenic Centers ◽  
Catalytic Asymmetric ◽  
Quaternary Stereogenic Centers

Construction of spirocycles containing highly substituted pyrroli-dine and 1-indanone motifs with spiro quaternary stereogenic centers via 1,3-dipolar cycloaddition of 2-alkylidene-1-indanone and azomethine ylides promoted by simple imidazolium salts

RSC Advances ◽  
2015 ◽  
Vol 5 (87) ◽  
pp. 70910-70914 ◽  
Author(s):  
Wei-Qiang Hu ◽  
Yan-Su Cui ◽  
Zhi-Jun Wu ◽  
Chuan-Bao Zhang ◽  
Pei-Hao Dou ◽  
...  
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Imidazolium Salts ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

The 1,3-dipolar cycloaddition of 2-alkylidene-1-indanone with azomethine ylides has been successfully developed promoted by simple imidazolium salts to construct a variety of spirocycles, containing highly substituted pyrrolidines, in excellent yields (up to 99%).

Cu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with dimethyl itaconate and 2-methyleneglutarate

RSC Advances ◽  
2014 ◽  
Vol 4 (32) ◽  
pp. 16899-16905 ◽  
Author(s):  
Hai-Yan Tao ◽  
Zhao-Lin He ◽  
Yang Yang ◽  
Chun-Jiang Wang
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Stereogenic Centers ◽  
Efficient Construction ◽  
Catalytic Asymmetric ◽  
Dimethyl Itaconate

Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with dimethyl itaconate and 2-methyleneglutarate was realized with Cu(i)/TF–BiphamPhos complex as the catalyst for the efficient construction of pyrrolidine derivatives bearing one unique all carbon-quaternary and two tertiary stereogenic centers.

Organocatalytic synthesis of chiral CF3-containing oxazolidines and 1,2-amino alcohols: asymmetric oxa-1,3-dipolar cycloaddition of trifluoroethylamine-derived azomethine ylides

2020 ◽  
Vol 7 (21) ◽  
pp. 3452-3458
Author(s):  
Wen-Run Zhu ◽  
Qiong Su ◽  
Ning Lin ◽  
Qing Chen ◽  
Zhen-Wei Zhang ◽  
...  
Keyword(s):  
Amino Alcohols ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Stereogenic Centers

A series of CF3-containing oxazolidines were constructed via organocatalytic asymmetric oxa-1,3-dipolar cycloaddition. These oxazolidines could undergo facile conversion to CF3-containing 1,2-amino alcohols with vicinal stereogenic centers.

A Convenient Procedure for the Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides and Alkenes

2005 ◽  
Vol 7 (21) ◽  
pp. 4569-4572 ◽  
Author(s):  
Carlos Alemparte ◽  
Gonzalo Blay ◽  
Karl Anker Jørgensen
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Convenient Procedure ◽  
Catalytic Asymmetric
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