ChemInform Abstract: Catalytic Asymmetric Direct Vinylogous Michael Addition of Deconjugated Butenolides to Maleimides for the Construction of Quaternary Stereogenic Centers.

ChemInform ◽  
2013 ◽  
Vol 44 (18) ◽  
pp. no-no
Author(s):  
Madhu Sudan Manna ◽  
Santanu Mukherjee
Keyword(s):  
Michael Addition ◽  
Stereogenic Centers ◽  
Catalytic Asymmetric ◽  
Quaternary Stereogenic Centers

scholarly journals A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19402-19408
Author(s):  
Xuan Yu ◽  
Hui Bai ◽  
Dong Wang ◽  
Zhaohai Qin ◽  
Jia-Qi Li ◽  
...  
Keyword(s):  
Michael Addition ◽  
Quaternary Centers ◽  
Stereogenic Centers ◽  
Convenient Approach ◽  
Quaternary Stereogenic Centers

Ni(ii)-catalyzed enantioselective Michael addition afforded compounds with all-carbon quaternary stereogenic centers featuring a CF2H group in good enantioselectivities.

Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates

2017 ◽  
Vol 15 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Lijun Zhang ◽  
Wenzhong Zhang ◽  
Haibo Mei ◽  
Jianlin Han ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Aldol Reactions ◽  
Addition Reactions ◽  
Asymmetric Aldol ◽  
Wide Range ◽  
Stereogenic Centers ◽  
New Type ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Quaternary Stereogenic Centers

Cu(i)/bisoxazoline ligand catalyzed asymmetric aldol reactions of fluoro-indolinone derived new type tertiary enolates have been developed. This process allows the preparation of a wide range of α-fluoro-β-aryl/hetaryl/alkyl-β-hydroxy-indolin-2-one products containing C–F quaternary stereogenic centers.

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