ChemInform Abstract: Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols.

ChemInform ◽  
2012 ◽  
Vol 43 (14) ◽  
pp. no-no
Author(s):  
Hyunjin Kim ◽  
Yoon Kyung Choi ◽  
Jusuk Lee ◽  
Eungyeong Lee ◽  
Jaiwook Park ◽  
...  
Keyword(s):  
Burkholderia Cepacia ◽  
Kinetic Resolution ◽  
Ionic Surfactant ◽  
Secondary Alcohols ◽  
Dynamic Kinetic Resolution ◽  
Burkholderia Cepacia Lipase ◽  
Highly Active ◽  
Enantioselective Catalyst

Improved synthesis of Bn5CpRu(CO)2Cl and its application as racemization catalyst in preparative-scale metalloenzymatic dynamic kinetic resolution of 1-phenylethanol

2010 ◽  
Vol 83 (3) ◽  
pp. 479-487 ◽  
Author(s):  
Denys Mavrynsky ◽  
Liisa T. Kanerva ◽  
Reijo Sillanpää ◽  
Reko Leino
Keyword(s):  
Kinetic Resolution ◽  
Immobilized Enzyme ◽  
Metal Catalyst ◽  
Secondary Alcohols ◽  
Mass Loading ◽  
Dynamic Kinetic Resolution ◽  
Preparative Scale ◽  
Highly Active ◽  
Complex Forms

An improved gram-scale synthesis of Bn5CpRu(CO)2Cl is reported based on heating of pentabenzylcyclopentadiene with Ru3(CO)12 at 160 °C under argon atmosphere in mesitylene followed by addition of chloroform, continued heating, and evaporation of the solvents. Subsequent washing of unreacted ligand precursor with hexane provided pure title compound in 77 % yield. In combination with Candida antarctica lipase B (CAL-B) (Novozym 435), this complex forms a highly active racemization catalyst for metallo-enzymatic dynamic kinetic resolution (DKR) of secondary alcohols as demonstrated in the present work by converting 100 g of racemic 1-phenylethanol to (R)-1-phenylethanol in >99 % ee and 93 % overall yield over two steps using 0.05 mol % loading of the metal catalyst and 1 mass % loading of immobilized enzyme. In addition, the synthesis and crystallographic characterization of the palladium congener Bn5CpPd(PPh3)Cl are briefly discussed.

Kinetic resolution of secondary alcohols with Burkholderia cepacia lipase immobilized on a biodegradable ternary blend polymer matrix as a highly efficient and heterogeneous recyclable biocatalyst

RSC Advances ◽  
2015 ◽  
Vol 5 (6) ◽  
pp. 4592-4598 ◽  
Author(s):  
Ganesh V. More ◽  
Kirtikumar C. Badgujar ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Polymer Matrix ◽  
Burkholderia Cepacia ◽  
Kinetic Resolution ◽  
Recyclable Catalyst ◽  
High Conversion ◽  
Ternary Blend ◽  
Secondary Alcohols ◽  
Enantiomerically Pure ◽  
Burkholderia Cepacia Lipase ◽  
Blend Polymer

A greener and superficial protocol for the synthesis of enantiomerically pure alcohols and their enantioriched acetate derivatives using a biodegradable heterogeneous recyclable catalyst with high conversion has been developed.

Ionic-surfactant-coated subtilisin: activity, enantioselectivity, and application to dynamic kinetic resolution of secondary alcohols

2017 ◽  
Vol 15 (41) ◽  
pp. 8836-8844 ◽  
Author(s):  
Kyungwoo Kim ◽  
Eungyeong Lee ◽  
Cheolwoo Kim ◽  
Jaiwook Park ◽  
Mahn-Joo Kim
Keyword(s):  
Bacillus Licheniformis ◽  
Kinetic Resolution ◽  
Ionic Surfactant ◽  
Secondary Alcohols ◽  
Dynamic Kinetic Resolution ◽  
Kinetic Resolutions

The faster dynamic kinetic resolutions of secondary alcohols were achieved with ionic surfactant-coated Bacillus licheniformis subtilisin.

(S)-Selective Kinetic Resolution and Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols.

ChemInform ◽  
2006 ◽  
Vol 37 (16) ◽  
Author(s):  
Linnea Boren ◽  
Belen Martin-Matute ◽  
Yongmei Xu ◽  
Armando Cordova ◽  
Jan-E. Baeckvall
Keyword(s):  
Kinetic Resolution ◽  
Secondary Alcohols ◽  
Dynamic Kinetic Resolution

Efficient dynamic kinetic resolution of secondary alcohols with a novel tetrafluorosuccinato ruthenium complex

2006 ◽  
Vol 17 (15) ◽  
pp. 2299-2305 ◽  
Author(s):  
Sjoerd F.G.M. van Nispen ◽  
Jeroen van Buijtenen ◽  
Jef A.J.M. Vekemans ◽  
Jan Meuldijk ◽  
Lumbertus A. Hulshof
Keyword(s):  
Kinetic Resolution ◽  
Ruthenium Complex ◽  
Secondary Alcohols ◽  
Dynamic Kinetic Resolution

Lipase-mediated dynamic kinetic resolution (DKR) of secondary alcohols in the presence of zeolite using an ionic liquid solvent system

2015 ◽  
Vol 255 ◽  
pp. 41-48 ◽  
Author(s):  
Ken-ichi Shimomura ◽  
Hiroyuki Harami ◽  
Yui Matsubara ◽  
Toshiki Nokami ◽  
Naonobu Katada ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Kinetic Resolution ◽  
Solvent System ◽  
Secondary Alcohols ◽  
Dynamic Kinetic Resolution
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