secondary alcohols
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Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 231
Author(s):  
Yao Cui ◽  
Jixian Wang ◽  
Lei Yu ◽  
Ying Xu ◽  
David J. Young ◽  
...  

Solid supports functionalized with molecular metal catalysts combine many of the advantages of heterogeneous and homogeneous catalysis. A (NNN)Ru-incorporated porous organic polymer (POP-bp/bbpRuCl3) exhibited high catalytic efficiency and broad functional group tolerance in the C–C cross-coupling of secondary and primary alcohols to give β-alkylated secondary alcohols. This catalyst demonstrated excellent durability during successive recycling without leaching of Ru which is ascribed to the strong binding of the pincer ligands to the metal ions.


Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7475
Author(s):  
Yipeng You ◽  
Ming Yu Jin ◽  
Guanyu Tao ◽  
Xiangyou Xing

No matter through asymmetric reduction of ketones or kinetic resolution of secondary alcohols, enantioselective synthesis of the corresponding secondary alcohols is challenging when the two groups attached to the prochiral or chiral centers are spatially or electronically similar. For examples, dialkyl (sp3 vs. sp3), diaryl (sp2 vs. sp2), and aryl-alkenyl (sp2 vs. sp2) alcohols are difficult to produce with high enantioselectivities. By exploiting our recently developed Ru-catalysts of minimal stereogenicity, we reported herein a highly efficient kinetic resolution of aryl-alkenyl alcohols through hydrogen transfer. This method enabled such versatile chiral building blocks for organic synthesis as allylic alcohols, to be readily accessed with excellent enantiomeric excesses at practically useful conversions.


Author(s):  
Tsun-Ren Chen ◽  
Yu-Tung Chen ◽  
Yen-Hsing Lin ◽  
Hao-Chen Wang

A facile iridium/graphene-catalyzed methodology providing an efficient synthetic route for C-N bond formation is reported. This catalyst can directly promote the formation of C-N bonds, without pre-activation steps, and without solvents, alkalis and other additives. This protocol provides a direct N -alkylation of amines using a variety of primary and secondary alcohols with good selectivity and excellent yields. Charmingly, the use of diols resulted in intermolecular cyclization of amines, and such products are privileged structures in biologically active compounds. Two examples illustrate the advantages of this catalyst in organic synthesis: the tandem catalysis to synthesize hydroxyine, and the intermolecular cyclyzation to synthesize cyclizine. Water is the only by-product, which makes this catalytic process sustainable and environmentally friendly.


2021 ◽  
Vol 7 ◽  
pp. 1116-1124
Author(s):  
M.A. Mujtaba ◽  
Haeng Muk Cho ◽  
H.H. Masjuki ◽  
M.A. Kalam ◽  
M. Farooq ◽  
...  

2021 ◽  
pp. 153519
Author(s):  
Yuichi Kato ◽  
Tomoka Inoue ◽  
Yuuki Furuyama ◽  
Kenji Ohgane ◽  
Mahito Sadaie ◽  
...  

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