scholarly journals Decidual CXCR4 + CD56 bright NK cells as a novel NK subset in maternal–foetal immune tolerance to alleviate early pregnancy failure

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Vol 11 (10) ◽  
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Yu Tao ◽  
Yan‐Hong Li ◽  
Di Zhang ◽  
Ling Xu ◽  
Jia‐Jia Chen ◽  
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Author(s):  
Nandaram Seervi ◽  
Nupur Hooja ◽  
Lata Rajoria ◽  
Asha Verma ◽  
Kusum Malviya ◽  
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Michael Gdalevich ◽  
Ravit Nahum ◽  
Simion Meltcer ◽  
Eyal Y. Anteby ◽  
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2018 ◽  
Vol 33 (13) ◽  
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Alexis C. Gimovsky ◽  
Amelie Pham ◽  
Sindy C. Moreno ◽  
Sara Nicholas ◽  
Amanda Roman ◽  
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Author(s):  
Arti Kumari ◽  
Usha Kumari ◽  
Anupama Sinha

Introduction: Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy failure is varied and dose and route are not well established. AIM: To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. Results: Mean gestational age was 7.946+1.2 weeks. Mean induction abortion interval was 18.241+1.2 hours. Women with gestational age six to eight weeks had least mean induction-abortion interval time of 17.38+2.86. Mean dose required was 1560mcg. Efficacy of protocol was 92.85% in achieving complete abortion. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Thus by using a lower dose and appropriate interval between two doses (six hours), the side effects were lessened with high efficacy. Keywords: Efficacy, Missed Abortion, Misoprostol.


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