Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF-1 and TGB on cytologic material

2013 ◽  
Vol 42 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Srividya Sathiyamoorthy ◽  
Zahra Maleki
Keyword(s):  
Thyroid Carcinoma ◽  
Lung Adenocarcinoma ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma

scholarly journals Immunocytochemistry Test of Protein BRAF Expression for Diagnosis of Well Differentiated Thyroid Carcinoma

2018 ◽  
Vol 11 (3) ◽  
pp. 843-849 ◽  
Author(s):  
I. Wayan Sudarsa ◽  
Elvis Deddy Kurniawan Pualillin ◽  
Putu Anda Tusta Adiputra ◽  
Ida Bagus Tjakra Wibawa Manuaba
Keyword(s):  
Positive Predictive Value ◽  
Thyroid Carcinoma ◽  
Negative Predictive Value ◽  
Diagnostic Test ◽  
Predictive Value ◽  
Preoperative Diagnosis ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma ◽  
Inclusion Criteria

Background: Thyroid carcinoma generally has a good prognosis. The main focus of current research on thyroid carcinoma is to increase the accuracy of preoperative diagnosis of thyroid nodules. When the result of fine needle aspiration biopsy (FNAB) is indeterminate, clinicians often have doubts in determining the surgical management. Objective: Protein BRAF expression analysis can help improve the accuracy of FNAB and optimize the management of differentiated thyroid carcinoma. Methods: This study is a diagnostic test performed from October 2016 at Sanglah General Hospital with 38 patients as subjects who fulfilled the inclusion criteria. Data is being presented in descriptive form before diagnostic test is done to determine sensitivity, specificity, positive predictive value, negative predictive value and the accuracy of immunocytochemistry test for BRAF on indeterminate thyroid nodule. Results: Thirty-eight samples met the inclusion criteria during the study period. Three samples were male (7.9%) and 35 samples (92.1%) were female. The mean age of the sample was 45.21 years (SD ±10.910 years) with ages ranging from 23 to 66 years. Of the 12 samples undergoing isthmolobectomy, 7 samples (58.4%) were determined to be malignant from histopathological results. The sensitivity value of BRAF immunocytochemistry test is 45.45% with a specificity value of 81.25%, a positive predictive value of 76.92%, a negative predictive value of 52% and an accuracy of 60.50%. Analysis of the receiver operator (ROC) curve shows the area under the curve (AUC) of 63.4% with a confidence interval of 45.5–81.2%. Conclusion: Immunocytochemistry BRAF test have a reliable diagnostic value and can be taken into consideration in the preoperative diagnosis of thyroid malignancies.

Incremental Diagnostic Value of SPECT/CT with131I Scintigraphy after Radioiodine Therapy in Patients with Well-differentiated Thyroid Carcinoma

Radiology ◽  
2012 ◽  
Vol 265 (3) ◽  
pp. 902-909 ◽  
Author(s):  
Yasuhiro Maruoka ◽  
Koichiro Abe ◽  
Shingo Baba ◽  
Takuro Isoda ◽  
Hirofumi Sawamoto ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma ◽  
Well Differentiated

Serum Thyroglobulin Determinations in Patients with Differentiated Thyroid Carcinoma

1983 ◽  
Vol 22 (04) ◽  
pp. 204-211 ◽  
Author(s):  
J. Němec ◽  
V. Zamrazil ◽  
S. Váňa ◽  
D. Pohunková ◽  
S. Rohling ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Healthy Subjects ◽  
Distant Metastases ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma ◽  
Serum Thyroglobulin ◽  
Thyroglobulin Antibody ◽  
Long Term Follow Up

Serum thyroglobulin levels were measured in 636 patients with differentiated thyroid carcinoma, in whom altogether 1240 determinations were performed in different phases of disease and treatment. A modified sensitive radioimmunoassay was employed using an own high-specific thyroglobulin antibody. The results showed that both the majority of patients with functioning metastases accumulating radioiodine and with non-functioning metastases which could not be detected by scanning had higher serum TG levels, compared with a group of healthy subjects. However, “normal” TG values in patients with metastases, especially non-functioning, were found too. Thus, these findings decrease the diagnostic value of the TG determination. The highest TG values were found in patients with distant metastases of differentiated thyroid carcinoma (in lungs and bones); on the other hand, the proportion of patients with lymph-node(s) métastasés and “normal” TG levels was relatively high. We suggest that the serum TG determination cannot generally replace scanning with l31I and cannot serve as the only test, while being a helpful indicator in the long-term follow-up of differentiated thyroid cancer patients.

Differentiated thyroid carcinoma: Incremental diagnostic value of 131I SPECT/CT over planar whole body scan after radioiodine therapy

Endocrine ◽  
2016 ◽  
Vol 56 (3) ◽  
pp. 551-559 ◽  
Author(s):  
Valentina Zilioli ◽  
Alessia Peli ◽  
Maria Beatrice Panarotto ◽  
Giancarlo Magri ◽  
Ahmed Alkraisheh ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Whole Body Scan ◽  
Body Scan

Diagnostic value of serum thyroglobulin measurements in the follow-up of differentiated thyroid carcinoma, a structured meta-analysis

2004 ◽  
Vol 61 (1) ◽  
pp. 61-74 ◽  
Author(s):  
C. F. A. Eustatia-Rutten ◽  
J. W. A. Smit ◽  
J. A. Romijn ◽  
E. P. M. van der Kleij-Corssmit ◽  
A. M. Pereira ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Differentiated Thyroid Carcinoma ◽  
Serum Thyroglobulin
Sign in / Sign up

Export Citation Format

Share Document