scholarly journals Behavioral screening for neuroactive drugs in zebrafish

2012 ◽  
Vol 72 (3) ◽  
pp. 373-385 ◽  
Author(s):  
Jason Rihel ◽  
Alexander F. Schier
2021 ◽  
pp. 109830072110033
Author(s):  
Amy M. Briesch ◽  
Sandra M. Chafouleas ◽  
Jennifer N. Dineen ◽  
D. Betsy McCoach ◽  
Aberdine Donaldson

Research conducted to date provides a limited understanding of the landscape of school-based screening practices across academic, behavioral, and health domains, thus providing an impetus for the current survey study. A total of 475 K–12 school building administrators representing 409 unique school districts across the United States completed an online survey, which assessed current school-based screening practices across domains from the point of data collection to intervention selection. Whereas 70% to 81% of the respondents reported the use of universal screening across health and academic domains, respectively, only 9% of the respondents endorsed the use of universal social, emotional, and behavioral screening. In addition, discrepancies were identified across domains with regard to such factors as (a) who reviews screening data, (b) how screening data are used to determine student risk, and (c) how interventions are designed for those students demonstrating risk. The lack of consensus in practice calls for dissemination concerning best practices in the implementation of social, emotional, and behavioral screening; risk identification; and Tier 1 intervention.


2014 ◽  
Vol 130 (3) ◽  
pp. 172-177 ◽  
Author(s):  
J.-A. Witt ◽  
K. J. Werhahn ◽  
G. Krämer ◽  
C. Ruckes ◽  
E. Trinka ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anouk C. Tengeler ◽  
Tim L. Emmerzaal ◽  
Bram Geenen ◽  
Vivienne Verweij ◽  
Miranda van Bodegom ◽  
...  

AbstractExposure to antibiotic treatment has been associated with increased vulnerability to various psychiatric disorders. However, a research gap exists in understanding how adolescent antibiotic therapy affects behavior and cognition. Many antibiotics that target bacterial translation may also affect mitochondrial translation resulting in impaired mitochondrial function. The brain is one of the most metabolically active organs, and hence is the most vulnerable to impaired mitochondrial function. We hypothesized that exposure to antibiotics during early adolescence would directly affect brain mitochondrial function, and result in altered behavior and cognition. We administered amoxicillin, chloramphenicol, or gentamicin in the drinking water to young adolescent male wild-type mice. Next, we assayed mitochondrial oxidative phosphorylation complex activities in the cerebral cortex, performed behavioral screening and targeted mass spectrometry-based acylcarnitine profiling in the cerebral cortex. We found that mice exposed to chloramphenicol showed increased repetitive and compulsive-like behavior in the marble burying test, an accurate and sensitive assay of anxiety, concomitant with decreased mitochondrial complex IV activity. Our results suggest that only adolescent chloramphenicol exposure leads to impaired brain mitochondrial complex IV function, and could therefore be a candidate driver event for increased anxiety-like and repetitive, compulsive-like behaviors.


1973 ◽  
Vol 16 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Jeffrey L. Denburg ◽  
Richard D. O'Brien
Keyword(s):  

Zebrafish ◽  
2017 ◽  
Vol 14 (6) ◽  
pp. 526-535 ◽  
Author(s):  
Isac Silva de Jesus ◽  
Milena Ferreira ◽  
Urbano Lopes Silva-Júnior ◽  
José Antônio Alves-Gomes

2018 ◽  
Vol 167 (1) ◽  
pp. 77-91 ◽  
Author(s):  
Katharina Dach ◽  
Bianca Yaghoobi ◽  
Martin R Schmuck ◽  
Dennis R Carty ◽  
Kelly M Morales ◽  
...  

ChemMedChem ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. 375-384 ◽  
Author(s):  
Jacques Joubert ◽  
Werner J. Geldenhuys ◽  
Cornelis J. Van der Schyf ◽  
Douglas W. Oliver ◽  
Hendrik Gert Kruger ◽  
...  
Keyword(s):  

2021 ◽  
Vol 146 ◽  
pp. 106188
Author(s):  
Daniel Cerveny ◽  
Roman Grabic ◽  
Kateřina Grabicová ◽  
Tomáš Randák ◽  
D.G. Joakim Larsson ◽  
...  

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