Testing venous carbohydrate‐deficient transferrin or capillary phosphatidylethanol with concurrent ethyl glucuronide and ethyl palmitate hair tests to assess historical and recent alcohol use

2020 ◽  
Author(s):  
Lolita Tsanaclis ◽  
Marie Davies ◽  
Sian Bevan ◽  
James Nutt ◽  
Kim Bagley ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Ethyl Glucuronide ◽  
Ethyl Palmitate ◽  
Recent Alcohol Use ◽  
Carbohydrate Deficient Transferrin

scholarly journals Comparison of Ethyl Glucuronide and Carbohydrate-Deficient Transferrin in Different Body Fluids for Post-mortem Identification of Alcohol Use

2013 ◽  
Vol 49 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Juha Rainio ◽  
Sanna Ahola ◽  
Päivikki Kangastupa ◽  
Johanna Kultti ◽  
Heidi Tuomi ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Body Fluids ◽  
Ethyl Glucuronide ◽  
Post Mortem ◽  
Carbohydrate Deficient Transferrin

Glycoconjugates in the detection of alcohol abuse

2011 ◽  
Vol 39 (1) ◽  
pp. 365-369 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Sławomir Dariusz Szajda ◽  
Alina Kępka ◽  
Agata Szulc ◽  
Krzysztof Zwierz
Keyword(s):  
Alcohol Use ◽  
Alcohol Abuse ◽  
Hospital Admissions ◽  
Ethyl Esters ◽  
Ethyl Glucuronide ◽  
Transfer Protein ◽  
Apolipoprotein J ◽  
Oxidative Metabolites ◽  
Carbohydrate Deficient Transferrin ◽  
History Of

Up to 30% of all hospital admissions and health-care costs may be attributable to alcohol abuse. Ethanol, its oxidative metabolites, acetaldehyde and ROS (reactive oxygen species), non-oxidative metabolites of alcohol [e.g. FAEEs (fatty acid ethyl esters)] and the ethanol–water competition mechanism are all involved in the deregulation of glycoconjugate (glycoprotein, glycolipid and proteoglycan) metabolic processes including biosynthesis, modification, transport, secretion, elimination and catabolism. An increasing number of new alcohol biomarkers that are the result of alcohol-induced glycoconjugate metabolic errors have appeared in the literature. Glycoconjugate-related alcohol markers are involved in, or are a product of, altered glycoconjugate metabolism, e.g. CDT (carbohydrate-deficient transferrin), SA (sialic acid), plasma SIJ (SA index of apolipoprotein J), CETP (cholesteryl ester transfer protein), β-HEX (β-hexosaminidase), dolichol, EtG (ethyl glucuronide) etc. Laboratory tests based on changes in glycoconjugate metabolism are useful in settings where the co-operativeness of the patient is impaired (e.g. driving while intoxicated) or when a history of alcohol use is not available (e.g. after trauma). In clinical practice, glycoconjugate markers of alcohol use/abuse let us distinguish alcoholic from non-alcoholic tissue damage, having important implications for the treatment and management of diseases.

scholarly journals Combining Serum Carbohydrate-Deficient Transferrin and Hair Ethyl Glucuronide to Provide Optimal Information on Alcohol Use

2014 ◽  
Vol 60 (10) ◽  
pp. 1347-1348 ◽  
Author(s):  
Hugo Neels ◽  
Michel Yegles ◽  
Geert Dom ◽  
Adrian Covaci ◽  
Cleo L Crunelle
Keyword(s):  
Alcohol Use ◽  
Ethyl Glucuronide ◽  
Carbohydrate Deficient Transferrin ◽  
Optimal Information

Recent Alcohol Use and Episodic Heavy Drinking Among American Indian Youths

2014 ◽  
Vol 23 (5) ◽  
pp. 334-346 ◽  
Author(s):  
Keith A. King ◽  
Rebecca A. Vidourek ◽  
Mallory K. Hill
Keyword(s):  
Alcohol Use ◽  
American Indian ◽  
Heavy Drinking ◽  
Recent Alcohol Use

scholarly journals Pretreatment ethyl glucuronide levels predict response to a contingency management intervention for alcohol use disorders among adults with serious mental illness

2017 ◽  
Vol 26 (7) ◽  
pp. 673-675 ◽  
Author(s):  
Michael Gerard McDonell ◽  
Emily Leickly ◽  
Sterling McPherson ◽  
Jordan Skalisky ◽  
Katherine Hirchak ◽  
...  
Keyword(s):  
Mental Illness ◽  
Alcohol Use ◽  
Serious Mental Illness ◽  
Contingency Management ◽  
Alcohol Use Disorders ◽  
Ethyl Glucuronide ◽  
Management Intervention

Markers of chronic alcohol use in hair: Comparison of ethyl glucuronide and cocaethylene in cocaine users

2007 ◽  
Vol 172 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Lucia Politi ◽  
Alessandra Zucchella ◽  
Luca Morini ◽  
Cristiana Stramesi ◽  
Aldo Polettini
Keyword(s):  
Alcohol Use ◽  
Ethyl Glucuronide ◽  
Chronic Alcohol ◽  
Cocaine Users

Hair ethyl glucuronide is a highly accurate and objective biomarker of continued alcohol use in patients with alcoholic cirrhosis

2017 ◽  
Vol 66 (1) ◽  
pp. S349
Author(s):  
J. Verbeek ◽  
C.L. Crunelle ◽  
P. Michielsen ◽  
M. De Doncker ◽  
T. Roskams ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcoholic Cirrhosis ◽  
Ethyl Glucuronide

Ethyl Glucuronide and Ethyl Sulphate in Urine: Caution in their use as markers of recent alcohol use

2020 ◽  
Author(s):  
Isabella Mercurio ◽  
Pamela Politi ◽  
Eleonora Mezzetti ◽  
Fausto Agostinelli ◽  
Gianmarco Troiano ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Interindividual Variability ◽  
Ethyl Glucuronide ◽  
Urinary Concentration ◽  
Ethyl Sulfate ◽  
Time Points ◽  
Recent Alcohol Use ◽  
Ethanol Metabolites ◽  
Over Time

Abstract Aim To clarify the role of the ethanol metabolites, ethyl glucuronide (EtG) and ethyl sulfate (EtS), in monitoring alcohol consumption. Method We recruited 7 female and 17 male volunteers who were instructed to consume a quantity of beer (containing 48 gm ethanol) with food in one session. We examined urinary excretion of EtG and EtS over time and looked for correlations between the concentrations of the metabolites EtG and EtS. Results EtG concentrations in urine varied between 0.026 and 430.372 μg/ml with average values between 11.85 μg/ml (SD 19.75), 30 min after alcohol intake, and 100.39 μg/ml (SD 101.34), 4.5 h after alcohol intake. EtS urinary concentration ranged from 0.006 to 101.432 μg/ml with average values between 4.77 μg/ml (SD 5.42), 30 min after alcohol intake, and 30.14 μg/ml (SD 27.20), 4.5 h after alcohol intake. Spearman’s test showed that urinary EtG and EtS correlated significantly at several time points. Conclusion The great interindividual variability in their excretion suggests caution in the use of urinary measurement of these metabolites in forensic investigations.

scholarly journals Should We Use Carbohydrate-deficient Transferrin instead of γ-Glutamyltransferase for Detecting Problem Drinkers? A Systematic Review and Metaanalysis

2000 ◽  
Vol 46 (12) ◽  
pp. 1894-1902 ◽  
Author(s):  
Kay Scouller ◽  
Katherine M Conigrave ◽  
Petra Macaskill ◽  
Les Irwig ◽  
John B Whitfield
Keyword(s):  
Systematic Review ◽  
Liquid Chromatography ◽  
Alcohol Use ◽  
Roc Analysis ◽  
Problem Drinkers ◽  
Excessive Alcohol Consumption ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol ◽  
Assay Methods ◽  
Better Than

Abstract Background: Carbohydrate-deficient transferrin (CDT) has been used as a test for excessive alcohol consumption in research, clinical, and medico-legal settings, but there remain conflicting data on its accuracy, with sensitivities ranging from <20% to 100%. We examined evidence of its benefit over a conventional and less expensive test, γ-glutamyltransferase (GGT), and compared the accuracy of different CDT assay methods. Methods: We performed a systematic review using summary ROC analysis of 110 studies prior to June 1998 on the use of CDT in the detection of alcohol dependence or hazardous/harmful alcohol use. Results: We identified several potential sources of bias in studies. In studies examining CDT and GGT in the same subjects, subject characteristics were less likely to influence the comparison. In such paired studies, the original Pharmacia CDT assay was significantly more accurate than GGT, but the modified CDTect assay did not perform as well as the original and was not significantly better than GGT. The accuracy of the AXIS %CDT assay was statistically indistinguishable from modified CDTect. Several CDT assay methods appeared promising, in particular, liquid chromatography (chromatofocusing, HPLC, fast protein liquid chromatography) and isoelectric focusing, but there were insufficient paired studies from which to draw firm conclusions. Conclusions: In studies published before June 1998, the results obtained with commercially available CDT assays were not significantly better than GGT as markers of excessive alcohol use in paired studies. Further high-quality studies comparing CDTect (modified) and other CDT assays with GGT in the same subjects are needed.

scholarly journals A Randomized Controlled Trial of Ethyl Glucuronide-Based Contingency Management for Outpatients With Co-Occurring Alcohol Use Disorders and Serious Mental Illness

2017 ◽  
Vol 174 (4) ◽  
pp. 370-377 ◽  
Author(s):  
Michael G. McDonell ◽  
Emily Leickly ◽  
Sterling McPherson ◽  
Jordan Skalisky ◽  
Debra Srebnik ◽  
...  
Keyword(s):  
Mental Illness ◽  
Randomized Controlled Trial ◽  
Alcohol Use ◽  
Serious Mental Illness ◽  
Controlled Trial ◽  
Contingency Management ◽  
Alcohol Use Disorders ◽  
Ethyl Glucuronide ◽  
Randomized Controlled
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