Inhaled corticosteroids in children with persistent asthma: effects on growth

2014 ◽  
Vol 9 (4) ◽  
pp. 829-930 ◽  
Author(s):  
Linjie Zhang ◽  
Sílvio OM Prietsch ◽  
Francine M Ducharme
Keyword(s):  
Inhaled Corticosteroids ◽  
Persistent Asthma

CLINICAL AND SPIROGRAPHIC FEATURES OF BRONCHIAL ASTHMA IN SCHOOLCHILDREN DEPENDING ON THE DIFFERENT REGIMENS OF BASIC ANTI-INFLAMMATORY THERAPY

2020 ◽  
Vol 73 (1) ◽  
Author(s):  
Olena Koloskova ◽  
Tetiana Bilous ◽  
Galyna Bilyk ◽  
Kristina Buryniuk-Glovyak ◽  
Olena Korotun ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
High Specificity ◽  
Clinical Feature ◽  
Clinical Group ◽  
Comparison Groups ◽  
Anti Inflammatory ◽  
High Doses ◽  
Persistent Bronchial Asthma

The aim: To study the clinical and spirographic features persistence of the bronchial asthma in schoolchildren against the background of the alternative daily doses of inhaled corticosteroids to increase the effectiveness of anti-inflammatory therapy for this disease. Materials and methods: A complete comprehensive clinical-paraclinical examination of 65 schoolchildren with persistent asthma was conducted. According to the average daily dose of inhaled corticosteroids (ICS) the patients were divided into two clinical groups. The first (I) group consisted of 46 children who received ICS in the regimen of low-to-medium equipotent doses (253.95±9.98 μg per day), and the second (II) comparison group was formed of 19 patients who controlled the pBA using high doses of ICS (494.74±5.56 μg per day). Results: The patients of the І clinical group compared to patients of the ІІ group have a higher risk of the mild bronchial obstructive syndrome during asthma attacks. In assessing the level of control of persistent bronchial asthma using the CIA-scale, it was found that in II group cases of the controlled course of the disease were observed almost two times less than in children of the I group of comparison. In conducting spirography in children of comparison groups, it was shown that the ratio of indices of bronchospasm (FEV1/ FVC) was worse in patients receiving high doses of ICS. Conclusions: So, сharacteristic clinical feature of asthma controlled by high doses of ICS is more severe nature of bronchial obstructive syndrome during the period of exacerbation (OR=1.9-3.0). In the management of persistent bronchial asthma, the Gensler index which has high specificity (94.4%) and accuracy (92.2%) should be used for disease control verification.

scholarly journals Inhaled corticosteroids in children with persistent asthma: Effects on growth

2015 ◽  
Vol 20 (5) ◽  
pp. 248-250 ◽  
Author(s):  
Brian A Kuzik
Keyword(s):  
Inhaled Corticosteroids ◽  
Persistent Asthma

Effect of inhaled corticosteroids on linear growth in children with persistent asthma

2014 ◽  
Vol 15 (4) ◽  
pp. 322-324
Author(s):  
Linjie Zhang ◽  
Sílvio O.M. Prietsch
Keyword(s):  
Linear Growth ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma

Inhaled Corticosteroid Therapy for Asthma in Preschool Children: Growth Issues

PEDIATRICS ◽  
2002 ◽  
Vol 109 (Supplement_E1) ◽  
pp. 373-380
Author(s):  
David B. Allen
Keyword(s):  
Young Children ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Preventive Treatment ◽  
Growth Suppression ◽  
Mineral Density ◽  
Childhood Growth ◽  
Gh Secretion ◽  
Final Adult Height ◽  
Very Young Children

Although inhaled corticosteroids (ICS) have emerged as the preventive treatment of choice for persistent asthma, few studies have been conducted in infants and very young children that assess the benefits and risks of ICS therapy, particularly with regard to growth. Oral glucocorticoids inhibit growth at multiple levels by blunting pulsatile growth hormone (GH) secretion, decreasing insulin-like growth factor-1 bioactivity, and directly inhibiting new collagen synthesis. Normal childhood growth can be divided conceptually into 3 phases according to primary growth-supporting factors: nutrition-dependent growth of infancy, GH-dependent childhood growth, and sex steroid/GH stimulation of pubertal growth. Susceptibility to glucocorticoid-induced growth suppression appears to increase during periods of transition from one phase to another, particularly in the immediate prepubertal years. Studies using ICS at varying dosages demonstrate the possibility of short-term growth suppression, but long-term studies suggest a negligible effect, if any, on final adult height or bone mineral density. Although certain speculations regarding the safety of ICS use in infants and very young children can be made based on these data, age-specific studies are needed to account for effects of differences in oral versus airway deposition and growth axis resiliency, which may occur in these patients.

scholarly journals Comparison of combination inhalers vs inhaled corticosteroids alone in moderate persistent asthma

2003 ◽  
Vol 56 (5) ◽  
pp. 494-500 ◽  
Author(s):  
Daniel K. C. Lee ◽  
Catherine M. Jackson ◽  
Graeme P. Currie ◽  
Wendy J. Cockburn ◽  
Brian J. Lipworth
Keyword(s):  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Moderate Persistent Asthma
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