scholarly journals Microsatellite and major histocompatibility complex variation in an endangered rattlesnake, the Eastern Massasauga ( Sistrurus catenatus )

2016 ◽  
Vol 6 (12) ◽  
pp. 3991-4003 ◽  
Author(s):  
Collin P. Jaeger ◽  
Melvin R. Duvall ◽  
Bradley J. Swanson ◽  
Christopher A. Phillips ◽  
Michael J. Dreslik ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Sistrurus Catenatus ◽  
Complex Variation

Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants

2010 ◽  
Vol 62 (2) ◽  
pp. 85-100 ◽  
Author(s):  
Elizabeth A. Archie ◽  
Tammy Henry ◽  
Jesus E. Maldonado ◽  
Cynthia J. Moss ◽  
Joyce H. Poole ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

Stock Identification of Fraser River Sockeye Salmon Using Microsatellites and Major Histocompatibility Complex Variation

2004 ◽  
Vol 133 (5) ◽  
pp. 1117-1137 ◽  
Author(s):  
Terry D. Beacham ◽  
Michael Lapointe ◽  
John R. Candy ◽  
Brenda McIntosh ◽  
Cathy MacConnachie ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Sockeye Salmon ◽  
Stock Identification ◽  
Fraser River ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

Major histocompatibility complex variation in insular populations of the Egyptian vulture: inferences about the roles of genetic drift and selection

2011 ◽  
Vol 20 (11) ◽  
pp. 2329-2340 ◽  
Author(s):  
ROSA AGUDO ◽  
MIGUEL ALCAIDE ◽  
CIRO RICO ◽  
JESUS A. LEMUS ◽  
GUILLERMO BLANCO ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Genetic Drift ◽  
Major Histocompatibility ◽  
Egyptian Vulture ◽  
Histocompatibility Complex ◽  
Complex Variation ◽  
Insular Populations

Immunocontraceptive vaccines and major histocompatibility complex variation in the brushtail possum

2010 ◽  
Vol 86 (1) ◽  
pp. 36
Author(s):  
O.J. Holland ◽  
P.E. Cowan ◽  
D.M. Gleeson ◽  
J.A. Duckworth ◽  
L.W. Chamley
Keyword(s):  
Major Histocompatibility Complex ◽  
Brushtail Possum ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

Estimation of Stock Composition and Individual Identification of Sockeye Salmon on a Pacific Rim Basis Using Microsatellite and Major Histocompatibility Complex Variation

2005 ◽  
Vol 134 (5) ◽  
pp. 1124-1146 ◽  
Author(s):  
Terry D. Beacham ◽  
John R. Candy ◽  
Brenda McIntosh ◽  
Cathy MacConnachie ◽  
Amy Tabata ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Sockeye Salmon ◽  
Pacific Rim ◽  
Individual Identification ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

Major histocompatibility complex variation at three class II loci in the northern elephant seal

2004 ◽  
Vol 13 (3) ◽  
pp. 711-718 ◽  
Author(s):  
Diana S. Weber ◽  
Brent S. Stewart ◽  
John Schienman ◽  
Niles Lehman
Keyword(s):  
Major Histocompatibility Complex ◽  
Class Ii ◽  
Elephant Seal ◽  
Major Histocompatibility ◽  
Northern Elephant Seal ◽  
Histocompatibility Complex ◽  
Complex Variation

Major histocompatibility complex variation at class II DQA locus in the brown hare (Lepus europaeus)

2009 ◽  
Vol 18 (22) ◽  
pp. 4631-4649 ◽  
Author(s):  
E. A. KOUTSOGIANNOULI ◽  
K. A. MOUTOU ◽  
T. SARAFIDOU ◽  
C. STAMATIS ◽  
V. SPYROU ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Class Ii ◽  
Lepus Europaeus ◽  
Brown Hare ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

scholarly journals Major Histocompatibility Complex Variation in the Endangered Przewalski’s Horse

Genetics ◽  
1999 ◽  
Vol 152 (4) ◽  
pp. 1701-1710
Author(s):  
Philip W Hedrick ◽  
Karen M Parker ◽  
Ellen L Miller ◽  
Philip S Miller
Keyword(s):  
Major Histocompatibility Complex ◽  
Stop Codon ◽  
Amino Acid Position ◽  
Major Histocompatibility ◽  
Related Sequence ◽  
Histocompatibility Complex ◽  
In The Wild ◽  
Complex Variation ◽  
Przewalski's Horse ◽  
Przewalski’S Horse

Abstract The major histocompatibility complex (MHC) is a fundamental part of the vertebrate immune system, and the high variability in many MHC genes is thought to play an essential role in recognition of parasites. The Przewalski’s horse is extinct in the wild and all the living individuals descend from 13 founders, most of whom were captured around the turn of the century. One of the primary genetic concerns in endangered species is whether they have ample adaptive variation to respond to novel selective factors. In examining 14 Przewalski’s horses that are broadly representative of the living animals, we found six different class II DRB major histocompatibility sequences. The sequences showed extensive nonsynonymous variation, concentrated in the putative antigen-binding sites, and little synonymous variation. Individuals had from two to four sequences as determined by single-stranded conformation polymorphism (SSCP) analysis. On the basis of the SSCP data, phylogenetic analysis of the nucleotide sequences, and segregation in a family group, we conclude that four of these sequences are from one gene (although one sequence codes for a nonfunctional allele because it contains a stop codon) and two other sequences are from another gene. The position of the stop codon is at the same amino-acid position as in a closely related sequence from the domestic horse. Because other organisms have extensive variation at homologous loci, the Przewalski’s horse may have quite low variation in this important adaptive region.

scholarly journals INITIAL CHARACTERIZATION OF MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS IIB EXON 2 IN AN ENDANGERED RATTLESNAKE, THE EASTERN MASSASAUGA (SISTRURUS CATENATUS)

2014 ◽  
pp. 98-104 ◽  
Author(s):  
Collin P. Jaeger ◽  
Richard B. King ◽  
Melvin R. Duvall
Keyword(s):  
Major Histocompatibility Complex ◽  
Positive Selection ◽  
Balancing Selection ◽  
Population Level ◽  
Major Histocompatibility ◽  
Exon 2 ◽  
Conservation Implications ◽  
Histocompatibility Complex ◽  
Sistrurus Catenatus ◽  
Mhc Class Iib

Genes of the major histocompatibility complex (MHC) play an important role in the vertebrate immune system and exhibit remarkably high levels of polymorphism, maintained by strong balancing selection. While the conservation implications of MHC variation have been explored in a variety of vertebrates, non-avian reptiles (most notably snakes) have received less attention. To address this gap and take the first steps toward more extensive population-level analyses, we cloned and sequenced MHC IIB exon 2 in an endangered rattlesnake, the Eastern Massasauga (Sistrurus catenatus). Based on three individuals, we found evidence of at least four putatively functional loci. These sequences exhibited relatively high levels of variation and significantly higher rates of nonsynonymous to synonymous substitutions, especially within the antigen-binding sites, indicating strong positive selection. Phylogenetic analysis revealed a pattern of trans-species polymorphism, also suggesting positive selection. These results contribute to our understanding of MHC variation in non-avian reptiles and form a basis for more studies of MHC variation in snakes of conservation concern.

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