Synthesis and Characterization of Bis(dithiolene) Tungsten(VI), -(V), and -(IV) Complexes and Their Reactivities in Coupled Electron–Proton Transfer: A New Series of Active Site Models of Tungstoenzymes

2007 ◽  
Vol 2007 (29) ◽  
pp. 4663-4668 ◽  
Author(s):  
Hideki Sugimoto ◽  
Makoto Tarumizu ◽  
Hiroyuki Miyake ◽  
Hiroshi Tsukube
Keyword(s):  
Proton Transfer ◽  
Active Site ◽  
Synthesis And Characterization ◽  
Electron Proton Transfer

Synthesis and characterization of multi-active site grafting starch copolymer initiated by KMnO 4 and HIO 4 /H 2 SO 4 systems

2015 ◽  
Vol 117 ◽  
pp. 247-254 ◽  
Author(s):  
Qiaoxia Guo ◽  
Yanqing Wang ◽  
Ya Fan ◽  
Xiwen Liu ◽  
Shenyong Ren ◽  
...  
Keyword(s):  
Active Site ◽  
Synthesis And Characterization

Synthesis and Characterization of Single, Double, and Triple Butterfly [2Fe2E] (E = Se, S) Cluster Complexes Related to the Active Site of [FeFe]-Hydrogenases

2011 ◽  
Vol 30 (15) ◽  
pp. 4097-4107 ◽  
Author(s):  
Wei Gao ◽  
Li-Cheng Song ◽  
Bang-Shao Yin ◽  
Hui-Ning Zan ◽  
De-Fu Wang ◽  
...  
Keyword(s):  
Active Site ◽  
Synthesis And Characterization ◽  
Cluster Complexes

Synthesis and characterization of MII(N2S)(SR) complexes (M = Co, Cu): Synthetic approximations to the active site in poplar plastocyanin

1980 ◽  
Vol 46 ◽  
pp. L101-L105 ◽  
Author(s):  
Jeffery S. Thompson ◽  
Joan L. Zitzmann ◽  
Tobin J. Marks ◽  
James A. Ibers
Keyword(s):  
Active Site ◽  
Synthesis And Characterization

Modeling the Active Site of Cytochrome Oxidase:  Synthesis and Characterization of a Cross-Linked Histidine−Phenol

2002 ◽  
Vol 124 (8) ◽  
pp. 1750-1760 ◽  
Author(s):  
Jenny A. Cappuccio ◽  
Idelisa Ayala ◽  
Gregory I. Elliott ◽  
Istvan Szundi ◽  
James Lewis ◽  
...  
Keyword(s):  
Cytochrome Oxidase ◽  
Active Site ◽  
Synthesis And Characterization

scholarly journals Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

2020 ◽  
Vol 477 (15) ◽  
pp. 2771-2790 ◽  
Author(s):  
Nikola Maraković ◽  
Anamarija Knežević ◽  
Igor Rončević ◽  
Xavier Brazzolotto ◽  
Zrinka Kovarik ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Proton Transfer ◽  
Structural Characterization ◽  
Active Site ◽  
In Vitro Testing ◽  
Active Site Residues

The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibited with tabun (GA), cyclosarin (GF), sarin (GB), and VX. Both enzymes showed the greatest affinity toward the methylimidazole derivative (III) of 2-hydroxyimino-N-(azidophenylpropyl)acetamide (I). The crystal structure was determined for the complex of oxime III within human BChE, confirming that all three binding groups interacted with active site residues. In the case of BChE inhibited by GF, oximes I (kr = 207 M−1 min−1) and III (kr = 213 M−1 min−1) showed better reactivation efficiency than the reference oxime 2-PAM. Finally, the key mechanistic steps in the reactivation of GF-inhibited BChE with oxime III were modeled using the PM7R6 method, stressing the importance of proton transfer from Nε of His438 to Oγ of Ser203 for achieving successful reactivation.

scholarly journals Carbon dioxide binding at a Ni/Fe center: synthesis and characterization of Ni(η1-CO2-κC) and Ni-μ-CO2-κC:κ2O,O′-Fe

2017 ◽  
Vol 8 (1) ◽  
pp. 600-605 ◽  
Author(s):  
Changho Yoo ◽  
Yunho Lee
Keyword(s):  
Carbon Dioxide ◽  
Active Site ◽  
Synthesis And Characterization ◽  
Fe Species

A heterobimetallic Ni-μ-CO2-κC:κ2O,O′-Fe species reminiscent of the CODH active site was synthesized, helping to elucidate the role of the unique iron.

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