An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium-Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution

2015 ◽  
Vol 2015 (27) ◽  
pp. 5949-5958 ◽  
Author(s):  
Marc Perez ◽  
Pierre-Georges Echeverria ◽  
Elsa Martinez-Arripe ◽  
Mehdi Ez Zoubir ◽  
Ridha Touati ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Kinetic Resolution ◽  
Asymmetric Reduction ◽  
Dynamic Kinetic Resolution

scholarly journals Asymmetric total synthesis of rotenoids via organocatalyzed dynamic kinetic resolution

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Saima Perveen ◽  
Shuang Yang ◽  
Miao Meng ◽  
Weici Xu ◽  
Guoxiang Zhang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Asymmetric Total Synthesis

Dynamic Kinetic Resolution for the Catalytic Asymmetric Total Synthesis of Antithrombotic Agents M58163 and M58169

2007 ◽  
Vol 349 (4-5) ◽  
pp. 617-628 ◽  
Author(s):  
Fumihiko Saitoh ◽  
Hidemitsu Nishida ◽  
Takafumi Mukaihira ◽  
Kohsuke Aikawa ◽  
Koichi Mikami
Keyword(s):  
Total Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Antithrombotic Agents ◽  
Asymmetric Total Synthesis ◽  
Catalytic Asymmetric

scholarly journals Diastereoselective Synthesis of b-Branched a-Amino Acids via Bio-catalytic Dynamic Kinetic Resolution

2021 ◽  
Author(s):  
Fuzhuo Li ◽  
Li-Cheng Yang ◽  
Jingyang Zhang ◽  
Jason Chen ◽  
Hans Renata
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Kinetic Resolution ◽  
Diastereoselective Synthesis ◽  
Mechanistic Studies ◽  
Dynamic Kinetic Resolution ◽  
Resolution Process ◽  
Biocatalytic Reaction

We report a biocatalytic transamination method to prepare a broad range of b-branched a-amino acids that proceeds with high diastereo- and enantioselectivity. Mechanistic studies show that the transformation proceeds through a dynamic kinetic resolution process that is unique to the optimal enzyme. To highlight its utility and practicality, the biocatalytic reaction is applied to the synthesis of several cyclic fragments and in the first total synthesis of jomthonic acid A.

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