Rhodium(III)-Catalyzed C-H Alkylation/Nucleophilic Addition Domino Reaction

2018 ◽  
Vol 2019 (4) ◽  
pp. 660-664 ◽  
Author(s):  
Mengyao Tang ◽  
Yunpeng Li ◽  
Shengnan Han ◽  
Lei Liu ◽  
Lutz Ackermann ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Domino Reaction

Asymmetric Thio-Michael/Nucleophilic Addition Domino Reaction with ChiralN-Sulfinimines

2007 ◽  
Vol 72 (9) ◽  
pp. 3569-3572 ◽  
Author(s):  
Akio Kamimura ◽  
Hidenori Okawa ◽  
Yuki Morisaki ◽  
Shingo Ishikawa ◽  
Hidemitsu Uno
Keyword(s):  
Nucleophilic Addition ◽  
Domino Reaction

scholarly journals First Zinc Bromide Promoted Annulative Domino Reactions between Enamines and Cyclic Morita–Baylis–Hillman Alcohols: Synthesis of N,O-Ketals

Synlett ◽  
2020 ◽  
Vol 31 (13) ◽  
pp. 1282-1286
Author(s):  
Farhat Rezgui ◽  
Ghalia Bouhalleb ◽  
Ahmed Meddeb ◽  
Noura Fakhar Bourguiba ◽  
Julien Legros ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Conjugate Addition ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Zinc Bromide ◽  
Iminium Ion

A new efficient ZnBr2-mediated annulative domino reaction between enamines and cyclic Morita–Baylis–Hillman (MBH) alcohols is disclosed. The process involves a tandem sequence (intermolecular conjugate addition of enamines to MBH alcohols and intramolecular nucleophilic addition of the hydroxyl moiety to the transiently generated iminium ion), affording the corresponding N,O-ketals diastereoselectively in good yields.

Synthesis of Potential Anticancer 1-(1H-Indol-3-yl)isoquinolines by Silver Nitrate Mediated Tandem Reactions of 2-Alkynyl­benzaldehyde Azines and Indoles

Synlett ◽  
2018 ◽  
Vol 29 (06) ◽  
pp. 773-778 ◽  
Author(s):  
Yun-Hui Zhao ◽  
Zhihua Zhou ◽  
Yong-Cheng Ma ◽  
Yueyang Luo ◽  
Yingli Zhu ◽  
...  
Keyword(s):  
Silver Nitrate ◽  
Nucleophilic Addition ◽  
Bond Cleavage ◽  
Domino Reaction ◽  
Reference Compound ◽  
Lead Compounds ◽  
Mild Conditions ◽  
Antitumor Compounds ◽  
Interesting Class

Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramolecular cyclization, nucleophilic addition of indole, and subsequent N–N bond cleavage. The transformation from readily available starting materials into an interesting class of indole-substituted isoquinolines was completed under mild conditions and by simple operations in moderate to good yields. The antitumor activity of these compounds in vitro was significantly greater than that of a reference compound, 5-fluorouracil. The products might serve as new lead compounds for drugs for the treatment of cancer.

A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole

2018 ◽  
Vol 54 (69) ◽  
pp. 9611-9614 ◽  
Author(s):  
Shikuan Su ◽  
Jianxiong Li ◽  
Mingming Sun ◽  
Hongbin Zhao ◽  
Yali Chen ◽  
...  
Keyword(s):  
Michael Addition ◽  
Nucleophilic Addition ◽  
Domino Reaction

An unusual domino reaction of 2-isocyanophenyloxyacrylate and aryne has been disclosed. The present strategy experiences nucleophilic addition, Michael addition, carbon–oxygen cleavage, and cyclization, thus enabling the quick aryne vicinal difunctionalization by the installation of a benzoxazole and an olefin.

scholarly journals A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-diones with Aminocrotonic Acid Esters

2017 ◽  
Author(s):  
Khidmet Shikhaliev ◽  
Artem Sabynin ◽  
Valeri Sekirin ◽  
Michael Krysin ◽  
Fedor Zubkov ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Domino Reaction ◽  
Synthetic Approach ◽  
Synthetic Route ◽  
Stereoselective Reaction ◽  
Acid Esters

A new synthetic approach to polyfunctional hexahydropyrrolo[3,4-b]pyrroles was developed based on cyclization of N-arylbromomaleimides with aminocrotonic acid esters. A highly chemo- and stereoselective reaction is a Hantzsch-type domino process, involving the steps of initial nucleophilic C-addition or substitution and subsequent intramolecular nucleophilic addition without recyclyzation of imide cycle.

Asymmetric Thio-Michael/Nucleophilic Addition Domino Reaction with Chiral N-Sulfinimines.

ChemInform ◽  
2007 ◽  
Vol 38 (34) ◽  
Author(s):  
Akio Kamimura ◽  
Hidenori Okawa ◽  
Yuki Morisaki ◽  
Shingo Ishikawa ◽  
Hidemitsu Uno
Keyword(s):  
Nucleophilic Addition ◽  
Domino Reaction

Synthesis of β-cyanopropan-1-one derivates by domino reaction

2014 ◽  
Vol 16 (7) ◽  
pp. 3454-3457 ◽  
Author(s):  
Hong-Ru Dong ◽  
Wang-Jun Dong ◽  
Rong-Shan Li ◽  
Yi-Ming Hu ◽  
Heng-Shan Dong ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Domino Reaction ◽  
Nucleophilic Addition Reaction ◽  
Low Toxicity

Polysubstituted β-cyanopropan-1-one was synthesized by the domino nucleophilic addition reaction of four-component Al2O3-catalyzed and low-toxicity reagents.

Recent Progress in Chemosensors Using Aldehyde-bearing Fluorophores for the Detection of Specific Analytes and their Bioimaging

2019 ◽  
Vol 26 (21) ◽  
pp. 4003-4028 ◽  
Author(s):  
Fangjun Huo ◽  
Yaqiong Zhang ◽  
Caixia Yin
Keyword(s):  
Biomedical Research ◽  
Nucleophilic Addition ◽  
Recent Progress ◽  
Biological Imaging ◽  
Tissue Imaging ◽  
Fluorescence Probes ◽  
Biological Applications ◽  
Convenient Procedure ◽  
Nucleophilic Mechanism

In recent years, aldehyde-appended fluorescence probes have attracted increasing attention. Fluorescent biological imaging includes many modern applications for cell and tissue imaging in biomedical research. Meanwhile, the nucleophilic mechanism is a very simple and convenient procedure for the preparation of aldehyde-sensing probes. This tutorial review focuses on aldehyde-bearing chemosensors based on nucleophilic addition mechanism with biological applications.

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