Recent Progress in Chemosensors Using Aldehyde-bearing Fluorophores for the Detection of Specific Analytes and their Bioimaging

2019 ◽  
Vol 26 (21) ◽  
pp. 4003-4028 ◽  
Author(s):  
Fangjun Huo ◽  
Yaqiong Zhang ◽  
Caixia Yin
Keyword(s):  
Biomedical Research ◽  
Nucleophilic Addition ◽  
Recent Progress ◽  
Biological Imaging ◽  
Tissue Imaging ◽  
Fluorescence Probes ◽  
Biological Applications ◽  
Convenient Procedure ◽  
Nucleophilic Mechanism

In recent years, aldehyde-appended fluorescence probes have attracted increasing attention. Fluorescent biological imaging includes many modern applications for cell and tissue imaging in biomedical research. Meanwhile, the nucleophilic mechanism is a very simple and convenient procedure for the preparation of aldehyde-sensing probes. This tutorial review focuses on aldehyde-bearing chemosensors based on nucleophilic addition mechanism with biological applications.

scholarly journals Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Udisha Singh ◽  
Vinod Morya ◽  
Bhaskar Datta ◽  
Chinmay Ghoroi ◽  
Dhiraj Bhatia
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Dna Nanotechnology ◽  
Research Area ◽  
Biological Applications ◽  
Stimuli Responsive ◽  
Future Prospects ◽  
Dna Structures ◽  
Challenges And Opportunities

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.

scholarly journals Bio-surface engineering with DNA scaffolds for theranostic applications

2018 ◽  
Vol 4 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Xiwei Wang ◽  
Wei Lai ◽  
Tiantian Man ◽  
Xiangmeng Qu ◽  
Li Li ◽  
...  
Keyword(s):  
Recent Progress ◽  
Surface Engineering ◽  
Dna Nanotechnology ◽  
Three Dimensions ◽  
High Yield ◽  
Biological Applications ◽  
Dna Nanostructures ◽  
Surface Functionality ◽  
Recognition Ability ◽  
Theranostic Applications

Abstract Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various “art-like” DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.

scholarly journals Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

2020 ◽  
Vol 10 (20) ◽  
pp. 7308
Author(s):  
Wendi Gao ◽  
Libo Zhao ◽  
Zhuangde Jiang ◽  
Dong Sun
Keyword(s):  
Success Rate ◽  
Genome Editing ◽  
Biomedical Research ◽  
Genetic Diagnosis ◽  
Biological Imaging ◽  
Robotic Systems ◽  
Current Development ◽  
Insufficient Information ◽  
Processing Methods ◽  
Future Extension

Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation information of targeted specimens. The complexity of the intracellular environment causes difficulties in visualizing manipulation tools and specimens. This review summarizes and analyzes the current development of advanced biological imaging sampling and computational processing methods in intracellular micromanipulation applications. It also discusses the related limitations and future extension, providing an important reference about this field.

Microcolumn liquid chromatography: a tool of potential significance in biomedical research.

1980 ◽  
Vol 26 (10) ◽  
pp. 1474-1479 ◽  
Author(s):  
M Novotny
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Biomedical Research ◽  
High Performance ◽  
Recent Progress ◽  
High Efficiency ◽  
Potential Significance ◽  
Microcolumn Liquid Chromatography ◽  
High Efficiency Separations

Abstract Recent progress in the area of microcolumn HPLC is reviewed with an emphasis on biomedically important directions. The potential of high efficiency separations, additional advantages of solvent economy, and the development of new detection and ancillary techniques of high-performance liquid chromatography are also discussed.

Para-sulfonatocalix[n]arene-based biomaterials: Recent progress in pharmaceutical and biological applications

2020 ◽  
Vol 190 ◽  
pp. 112121 ◽  
Author(s):  
Ehsan Bahojb Noruzi ◽  
Morteza Molaparast ◽  
Mojtaba Zarei ◽  
Behrouz Shaabani ◽  
Zahra Kariminezhad ◽  
...  
Keyword(s):  
Recent Progress ◽  
Biological Applications

Recent progress in the design and applications of fluorescence probes containing crown ethers

2017 ◽  
Vol 46 (9) ◽  
pp. 2437-2458 ◽  
Author(s):  
Jun Li ◽  
Dajeong Yim ◽  
Woo-Dong Jang ◽  
Juyoung Yoon
Keyword(s):  
Crown Ethers ◽  
Nobel Prize ◽  
Recent Progress ◽  
Chemical Compounds ◽  
Fluorescence Probes ◽  
Multiple Rings

Crown ethers, discovered by the winner of the Nobel Prize Charles Pedersen, are cyclic chemical compounds that consist of a ring or multiple rings containing several ether groups that are capable of binding various ions.

scholarly journals From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD, April 19–21, 2006

2006 ◽  
Vol 174 (4) ◽  
pp. 481-484 ◽  
Author(s):  
Yu-li Wang ◽  
Klaus M. Hahn ◽  
Robert F. Murphy ◽  
Alan F. Horwitz
Keyword(s):  
Cell Biology ◽  
Live Cell Imaging ◽  
Recent Progress ◽  
Cell Imaging ◽  
Live Cell ◽  
The Other ◽  
Biological Applications ◽  
Research Fields ◽  
Recent Meeting ◽  
The One

A recent meeting entitled Frontiers in Live Cell Imaging was attended by more than 400 cell biologists, physicists, chemists, mathematicians, and engineers. Unlike typical special topics meetings, which bring together investigators in a defined field primarily to review recent progress, the purpose of this meeting was to promote cross-disciplinary interactions by introducing emerging methods on the one hand and important biological applications on the other. The goal was to turn live cell imaging from a “technique” used in cell biology into a new exploratory science that combines a number of research fields.

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