Sample displacement chromatography of monoclonal antibody charge variants and aggregates

2021 ◽  
Author(s):  
Urh Černigoj ◽  
Blaž Nemec ◽  
Aleš Štrancar
Keyword(s):  
Monoclonal Antibody ◽  
Displacement Chromatography ◽  
Charge Variants

Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products

2017 ◽  
Vol 12 (11) ◽  
pp. 1700133 ◽  
Author(s):  
Nikhil Kateja ◽  
Devashish Kumar ◽  
Avinash Godara ◽  
Vijesh Kumar ◽  
Anurag S. Rathore
Keyword(s):  
Monoclonal Antibody ◽  
Simultaneous Separation ◽  
Charge Variants

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

Does interaction of monoclonal antibody charge variants with VEGF-A and ELISA reagents affect its quantification?

2020 ◽  
Vol 590 ◽  
pp. 113513 ◽  
Author(s):  
Shravan Sreenivasan ◽  
Deepak Kumar ◽  
Himanshu Malani ◽  
Anurag S. Rathore
Keyword(s):  
Monoclonal Antibody ◽  
Charge Variants

Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies

2019 ◽  
Vol 1586 ◽  
pp. 40-51 ◽  
Author(s):  
Ohnmar Khanal ◽  
Vijesh Kumar ◽  
Karin Westerberg ◽  
Fabrice Schlegel ◽  
Abraham M. Lenhoff
Keyword(s):  
Monoclonal Antibodies ◽  
Displacement Chromatography ◽  
Charge Variants
Sign in / Sign up

Export Citation Format

Share Document