An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

Multiple heteroatom-doped photoluminescent carbon dots for ratiometric detection of Hg2+ ions in cell imaging and environmental applications

Photoluminescent detection and imaging of Hg2+ ions in the biochemical living system are of great importance. In this study, a new photoluminescent probe based on nitrogen (N), sulfur (S), and...

A simple sensing platform based on 1T@2H-MoS2/cMWCNTs composite modified electrode for ultrasensitive detection of the illegal Sudan I dye in food samples

The work presented here describes a highly sensitive and simple electrochemical sensor for the detection of Sudan I dye based on MoS2 heterogeneous nanosheets (1T@2H-MoS2) and carboxylated carbon nanotubes (cMWCNTs)...

Green synthesis, characterization of Radix Hedysari-mediated silver nanoparticles and its sensitive colorimetric detection for Pb2+ in Yellow River Medium

In this study, a safe, rapid, and environment-friendly green synthesis for silver nanoparticles using the alcohol extract of Radix Hedysari (RH-AgNPs) was developed, the alcohol extract of Radix Hedysari (RH)...

A self-oriented beacon liquid crystal assay for kanamycin detection with AuNPs signal enhanced

The authors report a self-oriented beacon liquid crystal (LC) biosensor for kanamycin (Kana) detection with gold nanoparticles (AuNPs) signal enhanced. In this study, an assay was proposed for Kana detection...

Evaluation of a Porous Imine-Based Covalent Organic Framework for Solid-Phase Extraction of Nitroimidazoles

Covalent organic framework materials (COFs), a kind of porous organic material, have excellent potential application in the field of sample pretreatment due to their high surface areas and thermal stability....

An automated microfluidic platform for the screening and characterization of novel hepatitis B virus capsid assembly modulators

A fully automated microfluidic system was developed to screen for novel anti-HBV capsid assembly modulators. High-resolution dose–response curves were generated using convection-dominated Taylor–Aris dispersion of the screening compounds.