scholarly journals A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants

2021 ◽  
Author(s):  
Shu‐Ying Jing ◽  
Ce Shi ◽  
Hui Yi Leong ◽  
Jun‐Jie Yuan ◽  
Dong Gao ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Continuous Chromatography ◽  
Charge Variants

Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products

2017 ◽  
Vol 12 (11) ◽  
pp. 1700133 ◽  
Author(s):  
Nikhil Kateja ◽  
Devashish Kumar ◽  
Avinash Godara ◽  
Vijesh Kumar ◽  
Anurag S. Rathore
Keyword(s):  
Monoclonal Antibody ◽  
Simultaneous Separation ◽  
Charge Variants

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)

2010 ◽  
Vol 107 (4) ◽  
pp. 652-662 ◽  
Author(s):  
T. Müller-Späth ◽  
M. Krättli ◽  
L. Aumann ◽  
G. Ströhlein ◽  
M. Morbidelli
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Therapeutics ◽  
Continuous Chromatography

Does interaction of monoclonal antibody charge variants with VEGF-A and ELISA reagents affect its quantification?

2020 ◽  
Vol 590 ◽  
pp. 113513 ◽  
Author(s):  
Shravan Sreenivasan ◽  
Deepak Kumar ◽  
Himanshu Malani ◽  
Anurag S. Rathore
Keyword(s):  
Monoclonal Antibody ◽  
Charge Variants
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