SMARCA2‐NR4A3 is a novel fusion gene of extraskeletal myxoid chondrosarcoma identified by RNA next‐generation sequencing

2021 ◽  
Author(s):  
Shuanzeng Wei ◽  
Jianming Pei ◽  
Margaret Mehren ◽  
John A. Abraham ◽  
Arthur S. Patchefsky ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Fusion Gene ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Next Generation ◽  
Myxoid Chondrosarcoma ◽  
Generation Sequencing

scholarly journals Next generation sequencing of extraskeletal myxoid chondrosarcoma

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21770-21777 ◽  
Author(s):  
Elizabeth J. Davis ◽  
Yi-Mi Wu ◽  
Dan Robinson ◽  
Scott M. Schuetze ◽  
Laurence H. Baker ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Next Generation ◽  
Myxoid Chondrosarcoma ◽  
Generation Sequencing

VPS41-BRAF, a novel BRAF fusion gene identified in a lung adenocarcinoma patient by next-generation sequencing

Lung Cancer ◽  
2020 ◽  
Vol 146 ◽  
pp. 380-381
Author(s):  
Lujuan Wang ◽  
Anqi Chen ◽  
Xiaoling She ◽  
Juanjuan Xiang ◽  
Jingqun Tang
Keyword(s):  
Next Generation Sequencing ◽  
Lung Adenocarcinoma ◽  
Fusion Gene ◽  
Next Generation ◽  
Lung Adenocarcinoma Patient ◽  
Braf Fusion ◽  
Generation Sequencing

PLB1-ALK: A novel head-to-head fusion gene identified by next-generation sequencing in a lung adenocarcinoma patient

Lung Cancer ◽  
2021 ◽  
Vol 153 ◽  
pp. 176-178
Author(s):  
Bei Wang ◽  
Rongrong Chen ◽  
Changxi Wang ◽  
Huang Chen ◽  
Dingrong Zhong
Keyword(s):  
Next Generation Sequencing ◽  
Lung Adenocarcinoma ◽  
Fusion Gene ◽  
Next Generation ◽  
Lung Adenocarcinoma Patient ◽  
Generation Sequencing

scholarly journals A Novel ALK Fusion Gene (NSF-ALK) Identified in a Patient With Recurrent Spindle Cell Sarcoma Respond to Crizotinib: A Case Report

2020 ◽  
Author(s):  
Shuiling Jin ◽  
Lanling Weng ◽  
Qian Zhong ◽  
Chi Cui ◽  
Wenxue Tang ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Spindle Cell ◽  
Kinase Inhibitor ◽  
Fusion Gene ◽  
Spindle Cell Sarcoma ◽  
Next Generation ◽  
Cell Sarcoma ◽  
Anaplastic Lymphoma Kinase Inhibitor ◽  
Anaplastic Lymphoma ◽  
Generation Sequencing

Abstract Background: Spindle cell sarcoma (SCS) is a rare malignant tumor which relapses quickly and has poor prognosis.Case presentation: We report a case of SCS deriving from the left side of chestpossessed a novel unreported ALK fusion gene named NSF-ALK found by Next Generation Sequencing (NGS) technology. Despite receiving three surgical resections, local recurrence occurred rapidly and distant brain metastasis was eventually observed in this patient. The subsequent administration of crizotinib1, an oral anaplastic lymphoma kinase inhibitor, resulted in dramatic tumor shrinkage and the patient entered a remission period that has been ongoing for more than 10 months.Conclusions: In summary, this study is the first to describe a novel NSF-ALK fusion in spindle cell sarcoma which has promising efficacy by crizotinib treatment. More importantly, the case also shows that next generation sequencing provids more information of mutation to guide treatment in clinical decisions by presenting molecular changes.

scholarly journals SRBD1-ALK, a Novel ALK Fusion Gene Identified in an Adenocarcinoma Patient by Next-Generation Sequencing

2019 ◽  
Vol 14 (4) ◽  
pp. e72-e73 ◽  
Author(s):  
Xue Hou ◽  
Huamin Xu ◽  
Likun Chen
Keyword(s):  
Next Generation Sequencing ◽  
Fusion Gene ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiaodong Lyu ◽  
Jingke Yang ◽  
Xianwei Wang ◽  
Jieying Hu ◽  
Bing Liu ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Fusion Gene ◽  
Next Generation ◽  
Generation Sequencing
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