BOC‐PLAG1 , a new fusion gene of pleomorphic adenoma: Identified in a fine‐needle aspirate by RNA next‐generation sequencing

2021 ◽  
Author(s):  
Jianming Pei ◽  
Jeffrey C. Liu ◽  
Hormoz Ehya ◽  
Shuanzeng Wei
Keyword(s):  
Next Generation Sequencing ◽  
Pleomorphic Adenoma ◽  
Fusion Gene ◽  
Next Generation ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Generation Sequencing

Lung cancer adrenal gland metastasis: Optimal fine-needle aspirate and touch preparation smear cellularity characteristics for successful theranostic next-generation sequencing

2014 ◽  
Vol 122 (11) ◽  
pp. 822-832 ◽  
Author(s):  
Ferga C. Gleeson ◽  
Benjamin R. Kipp ◽  
Michael J. Levy ◽  
Jesse S. Voss ◽  
Michael B. Campion ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Adrenal Gland ◽  
Next Generation ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Adrenal Gland Metastasis ◽  
Touch Preparation ◽  
Generation Sequencing

Validation of Next-generation Sequencing on Fine Needle Aspirate Smears: Expanding the Reach of Molecular Testing

2017 ◽  
Vol 6 (5) ◽  
pp. S63-S64
Author(s):  
Alexandra Nichols ◽  
Edward Stelow ◽  
Daphne Jung ◽  
Anne Mills ◽  
Eli Williams
Keyword(s):  
Next Generation Sequencing ◽  
Molecular Testing ◽  
Next Generation ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Generation Sequencing

VPS41-BRAF, a novel BRAF fusion gene identified in a lung adenocarcinoma patient by next-generation sequencing

Lung Cancer ◽  
2020 ◽  
Vol 146 ◽  
pp. 380-381
Author(s):  
Lujuan Wang ◽  
Anqi Chen ◽  
Xiaoling She ◽  
Juanjuan Xiang ◽  
Jingqun Tang
Keyword(s):  
Next Generation Sequencing ◽  
Lung Adenocarcinoma ◽  
Fusion Gene ◽  
Next Generation ◽  
Lung Adenocarcinoma Patient ◽  
Braf Fusion ◽  
Generation Sequencing

Clinical Mutation Detection in Small Biopsies and Fine Needle Aspirations Including Bone Metastases Using a Next Generation Sequencing Assay

2015 ◽  
Vol 4 (6) ◽  
pp. S59
Author(s):  
Gang Zheng ◽  
Ming-Tseh Lin ◽  
Christopher Gocke ◽  
James Eshleman ◽  
Peter Illei
Keyword(s):  
Next Generation Sequencing ◽  
Bone Metastases ◽  
Mutation Detection ◽  
Next Generation ◽  
Fine Needle ◽  
Generation Sequencing

scholarly journals Next-Generation Sequencing Identifies Gene Mutations That Are Predictive of Malignancy in Residual Needle Rinses Collected From Fine-Needle Aspirations of Thyroid Nodules

2017 ◽  
Vol 142 (2) ◽  
pp. 178-183 ◽  
Author(s):  
Maren Y. Fuller ◽  
Dina Mody ◽  
April Hull ◽  
Kristi Pepper ◽  
Heather Hendrickson ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Thyroid Nodules ◽  
Gene Mutations ◽  
Braf V600e ◽  
Molecular Diagnostic ◽  
Thyroid Malignancy ◽  
Next Generation ◽  
Fine Needle ◽  
Thyroid Fna ◽  
Generation Sequencing

Context.— Thyroid nodules have a prevalence of approximately 70% in adults. Fine-needle aspiration (FNA) is a minimally invasive, cost-effective, standard method to collect tissue from thyroid nodules for cytologic examination. However, approximately 15% of thyroid FNA specimens cannot be unambiguously diagnosed as benign or malignant. Objective.— To investigate whether clinically actionable data can be obtained using next-generation sequencing of residual needle rinse material. Design.— A total of 24 residual needle rinse specimens with malignant (n = 6), indeterminate (n = 9), or benign (n = 9) thyroid FNA diagnoses were analyzed in our clinical molecular diagnostics laboratory using next-generation sequencing assays designed to detect gene mutations and translocations that commonly occur in thyroid cancer. Results were correlated with surgical diagnoses and clinical outcomes. Results.— Interpretable data were generated from 23 of 24 residual needle rinse specimens. Consistent with its well-known role in thyroid malignancy, BRAF V600E mutations were detected in 4 malignant cases. An NRAS mutation was detected in 1 benign case. No mutations were detected from specimens with indeterminate diagnoses. Conclusions.— Our data demonstrate that residual thyroid FNA needle rinses are an adequate source of material for molecular diagnostic testing. Importantly, detection of a mutation implicated in thyroid malignancy was predictive of the final surgical diagnosis and clinical outcome. Our strategy to triage thyroid nodules with indeterminate cytology with molecular testing eliminates the need to perform additional FNA passes into dedicated media or to schedule additional invasive procedures. Further investigation with a larger sample size to confirm the clinical utility of our proposed strategy is underway.

Detection of somatic mutations in fine needle aspirates of pancreatic cancer with next-generation sequencing.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e15225-e15225
Author(s):  
Joseph M. Herman ◽  
Vicente Valero ◽  
Christopher Lee Wolfgang ◽  
Christine A Iacobuzio-Donahue
Keyword(s):  
Pancreatic Cancer ◽  
Next Generation Sequencing ◽  
Somatic Mutations ◽  
Next Generation ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Generation Sequencing

scholarly journals Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics

2013 ◽  
Vol 27 (2) ◽  
pp. 314-327 ◽  
Author(s):  
Rashmi Kanagal-Shamanna ◽  
Bryce P Portier ◽  
Rajesh R Singh ◽  
Mark J Routbort ◽  
Kenneth D Aldape ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Solid Tumors ◽  
Gene Mutation ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Clinical Diagnostics ◽  
Next Generation ◽  
Fine Needle ◽  
Generation Sequencing ◽  
Mutation Profiling

Su1279 Factors of Endoscopic Ultrasound Fine-Needle Aspiration for Successful Next-Generation Sequencing in Pancreatic Cancer

2016 ◽  
Vol 83 (5) ◽  
pp. AB334
Author(s):  
Dong Hyo Noh ◽  
Joo Kyung Park ◽  
Kyu Taek Lee ◽  
Kwang Hyuck Lee ◽  
Jong Kyun Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Next Generation ◽  
Fine Needle ◽  
Generation Sequencing

scholarly journals Detection of BRAF V600E Mutations With Next-Generation Sequencing in Infarcted Thyroid Carcinomas After Fine-Needle Aspiration

2018 ◽  
Vol 150 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Erik Kouba ◽  
Andrew Ford ◽  
Charmaine G Brown ◽  
Chen Yeh ◽  
Gene P Siegal ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Braf V600e ◽  
Next Generation ◽  
Fine Needle ◽  
Thyroid Carcinomas ◽  
Generation Sequencing
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