scholarly journals Robust Rare Variant Association Testing for Quantitative Traits in Samples With Related Individuals

2013 ◽  
Vol 38 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Duo Jiang ◽  
Mary Sara McPeek
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Rare Variant Association ◽  
Association Testing ◽  
Related Individuals

scholarly journals Leveraging population information in family-based rare variant association analyses of quantitative traits

2016 ◽  
Vol 41 (2) ◽  
pp. 98-107 ◽  
Author(s):  
Yu Jiang ◽  
Yunqi Ji ◽  
Alexander B. Sibley ◽  
Yi-Ju Li ◽  
Andrew S. Allen
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Rare Variant Association ◽  
Association Analyses ◽  
Population Information ◽  
Family Based

scholarly journals A Statistical Approach for Rare-Variant Association Testing in Affected Sibships

2015 ◽  
Vol 96 (4) ◽  
pp. 543-554 ◽  
Author(s):  
Michael P. Epstein ◽  
Richard Duncan ◽  
Erin B. Ware ◽  
Min A. Jhun ◽  
Lawrence F. Bielak ◽  
...  
Keyword(s):  
Rare Variant ◽  
Statistical Approach ◽  
Rare Variant Association ◽  
Association Testing

scholarly journals Rare variant association testing in the non-coding genome

2020 ◽  
Vol 139 (11) ◽  
pp. 1345-1362
Author(s):  
Ozvan Bocher ◽  
Emmanuelle Génin
Keyword(s):  
Rare Variant ◽  
Rare Variant Association ◽  
Association Testing

scholarly journals Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

2011 ◽  
Vol 89 (1) ◽  
pp. 82-93 ◽  
Author(s):  
Michael C. Wu ◽  
Seunggeun Lee ◽  
Tianxi Cai ◽  
Yun Li ◽  
Michael Boehnke ◽  
...  
Keyword(s):  
Rare Variant ◽  
Association Test ◽  
Sequence Kernel Association Test ◽  
Sequencing Data ◽  
Rare Variant Association ◽  
Association Testing

scholarly journals Adjusting for Common Variant Polygenic Scores Improves Yield in Rare Variant Association Analyses

2021 ◽  
Author(s):  
Sean J. Jurgens ◽  
James P. Pirruccello ◽  
Seung Hoan Choi ◽  
Valerie N. Morrill ◽  
Mark D. Chaffin ◽  
...  
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Large Scale ◽  
Common Variant ◽  
Sequencing Data ◽  
Rare Variant Association ◽  
Association Analyses ◽  
Polygenic Scores ◽  
Association Discovery ◽  
The Uk

With the emergence of large-scale sequencing data, methods for improving power in rare variant analyses (RVAT) are needed. Here, we show that adjusting for common variant polygenic scores improves the yield in gene-based RVAT across 65 quantitative traits in the UK Biobank (up to 20% increase at α=2.6x10-6), without a marked increase in false-positive rates or genomic inflation. Our results illustrate how adjusting for common variant effects can aid in rare variant association discovery.

scholarly journals The effect of phenotypic outliers and non-normality on rare-variant association testing

2016 ◽  
Vol 24 (8) ◽  
pp. 1188-1194 ◽  
Author(s):  
Paul L Auer ◽  
Alex P Reiner ◽  
Suzanne M Leal
Keyword(s):  
Rare Variant ◽  
Rare Variant Association ◽  
Association Testing

A rare variant association test in family-based designs and non-normal quantitative traits

2015 ◽  
Vol 35 (6) ◽  
pp. 905-921 ◽  
Author(s):  
Lajmi Lakhal-Chaieb ◽  
Karim Oualkacha ◽  
Brent J. Richards ◽  
Celia M.T. Greenwood
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Association Test ◽  
Rare Variant Association ◽  
Family Based ◽  
Rare Variant Association Test

scholarly journals Powerful rare variant association testing in a copula‐based joint analysis of multiple phenotypes

2019 ◽  
Vol 44 (1) ◽  
pp. 26-40
Author(s):  
Stefan Konigorski ◽  
Yildiz E. Yilmaz ◽  
Jürgen Janke ◽  
Manuela M. Bergmann ◽  
Heiner Boeing ◽  
...  
Keyword(s):  
Rare Variant ◽  
Joint Analysis ◽  
Rare Variant Association ◽  
Association Testing ◽  
Multiple Phenotypes

A W-test collapsing method for rare-variant association testing in exome sequencing data

2016 ◽  
Vol 40 (7) ◽  
pp. 591-596 ◽  
Author(s):  
Rui Sun ◽  
Haoyi Weng ◽  
Inchi Hu ◽  
Junfeng Guo ◽  
William K. K. Wu ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Rare Variant ◽  
Sequencing Data ◽  
Rare Variant Association ◽  
Exome Sequencing Data ◽  
Association Testing
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