Single photon emission tomography in Alzheimer's disease. A longitudinal study of changes in relative regional cerebral blood flow

1991 ◽  
Vol 6 (11) ◽  
pp. 767-774 ◽  
Author(s):  
Michael P. Philpot ◽  
Durval C. Costa ◽  
Alistair Burns ◽  
Raymond Levy ◽  
Peter J. Ell
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Longitudinal Study ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Photon Emission Tomography

Effect of Central Cholinergic Stimulation on Regional Cerebral Blood Flow in Alzheimer's Disease

1991 ◽  
Vol 158 (4) ◽  
pp. 558-562 ◽  
Author(s):  
Ken Wilson ◽  
David Bowen ◽  
Paul Francis ◽  
Philippa Tyrrell
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Cholinergic Stimulation ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Photon Emission Tomography

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

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