Effect of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolemia

Hepatology ◽  
1992 ◽  
Vol 15 (6) ◽  
pp. 1072-1078 ◽  
Author(s):  
Giuseppe Mazzella ◽  
Paolo Parini ◽  
Davide Festi ◽  
Franco Bazzoli ◽  
Rita Aldini ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Cholic Acid ◽  
Biliary Lipid ◽  
Lipid Secretion

Changes in biliary lipid secretion and cholic acid kinetics induced by diet and diet + simvastatin in obese subjects

2000 ◽  
Vol 118 (4) ◽  
pp. A927
Author(s):  
Giuseppe Mazzella ◽  
Francesco Azzaroli ◽  
Pietro Fusaroli ◽  
Nicola Villanova ◽  
Marco Montagnani ◽  
...  
Keyword(s):  
Cholic Acid ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Obese Subjects

Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis

1999 ◽  
Vol 276 (3) ◽  
pp. G751-G760 ◽  
Author(s):  
David Q.-H. Wang ◽  
Frank Lammert ◽  
David E. Cohen ◽  
Beverly Paigen ◽  
Martin C. Carey
Keyword(s):  
Cholic Acid ◽  
Bile Flow ◽  
Cholesterol Biosynthesis ◽  
Cholesterol Absorption ◽  
Biliary Lipid ◽  
Biliary Cholesterol ◽  
Intestinal Cholesterol Absorption ◽  
Lipid Secretion ◽  
Lithogenic Diet ◽  
Secretion Rates

Cholic acid is a critical component of the lithogenic diet in mice. To determine its pathogenetic roles, we fed chow or 1% cholesterol with or without 0.5% cholic acid to C57L/J male mice, which because of lith genes have 100% gallstone prevalence rates. After 1 yr on the diets, we measured bile flow, biliary lipid secretion rates, hepatic cholesterol and bile salt synthesis, and intestinal cholesterol absorption. After hepatic conjugation with taurine, cholate replaced most tauro-β-muricholate in bile. Dietary cholic acid plus cholesterol increased bile flow and biliary lipid secretion rates and reduced cholesterol 7α-hydroxylase activity significantly mostly via deoxycholic acid, cholate’s bacterial 7α-dehydroxylation product but did not downregulate cholesterol biosynthesis. Intestinal cholesterol absorption doubled, and biliary cholesterol crystallized as phase boundaries shifted. Feeding mice 1% cholesterol alone produced no lithogenic or homeostatic effects. We conclude that in mice cholic acid promotes biliary cholesterol hypersecretion and cholelithogenesis by enhancing intestinal absorption, hepatic bioavailability, and phase separation of cholesterol in bile.

The effect of diet on bile acid kinetics and biliary lipid secretion in gallstone patients treated with ursodeoxycholic acid

1986 ◽  
Vol 43 (2) ◽  
pp. 239-250 ◽  
Author(s):  
P G Frenkiel ◽  
D W T Lee ◽  
H Cohen ◽  
C J Gilmore ◽  
K Resser ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Biliary Lipid ◽  
Lipid Secretion

scholarly journals Effect of some sulfonate analogues of ursodeoxycholic acid on biliary lipid secretion in the rat.

1996 ◽  
Vol 37 (6) ◽  
pp. 1181-1188
Author(s):  
T Mikami ◽  
K Kihira ◽  
S Ikawa ◽  
M Yoshii ◽  
E H Mosbach ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Biliary Lipid ◽  
Lipid Secretion

Effect of ursodeoxycholic acid administration on biliary lipid secretion in primary biliary cirrhosis

1989 ◽  
Vol 34 (S12) ◽  
pp. S52-S58 ◽  
Author(s):  
E. Roda ◽  
G. Mazzella ◽  
F. Bazzoli ◽  
N. Villanova ◽  
A. Minutello ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Biliary Cirrhosis ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Acid Administration
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