Infant Emotion Regulation Strategy Moderates Relations between Self-Reported Maternal Depressive Symptoms and Infant HPA Activity

2015 ◽  
pp. n/a-n/a ◽  
Author(s):  
Jennifer E. Khoury ◽  
Andrea Gonzalez ◽  
Robert Levitan ◽  
Mario Masellis ◽  
Vincenzo Basile ◽  
...  



2021 ◽  
Author(s):  
Vanessa Villani

Background: Gene-environment (GXE) interaction models have demonstrated that DRD2, DAT1, COMT, and OXTR SNPs moderate parental factors (i.e., maternal depression, parenting) to predict outcomes related to emotion regulation (e.g., affective problems, attentional control). No studies have investigated the connections between maternal maltreatment history and infant dopamine and oxytocin gene variants as they relate to infant emotion regulation. The current study addresses these gaps, evaluating the interaction of selected genes as they interact with maternal history of maltreatment to predict infant emotion regulation. Method: I investigated five infant genotypes (DRD2, DAT1, COMT, OXTR rs53576, and OXTR rs2254298) as they interacted with maternal history of self-reported maltreatment to predict observed infant emotion regulation behaviours. Self-reported maternal depressive symptoms were covaried. Infant emotion regulation was observed in the context of a potent stressor. I assessed three potential models of interaction, diathesis-stress, differential sensitivity, or vantage sensitivity. Results: Analyses demonstrated that, over and above maternal depressive symptoms, DRD2 and COMT significantly interacted with self-reported maternal maltreatment scores in a ‘vantage sensitivity’ model and DAT1 significantly interacted with maternal maltreatment history in a ‘diathesis-stress’ model. A cumulative vantage sensitivity (CVS) index significantly interacted with maternal maltreatment history to predict emotion regulation scores, consistent with a vantage sensitivity model. Conclusions: Findings indicated that infants with the “vantage” DRD2 (A1+) and COMT (Met) alleles, when exposed to mothers with lesser histories of maltreatment, fair better in terms of regulation than their non-susceptible counterparts. Infants with the “risk” DAT1 (presence of the 9-repeat) allele, when exposed to a parent with a greater history of maltreatment, tended to fare worse in terms of regulation behaviours. These differences in genetic interaction models suggest that an adaptive variation in genetic vulnerability and vantage-sensitivity, across an infant’s genome, can increase the possibility for optimal self-regulation outcomes, whether the environment is favourable or less favourable (i.e., lower versus higher history of maternal maltreatment, respectively).





Emotion ◽  
2020 ◽  
Author(s):  
Qiong Wu ◽  
Xin Feng ◽  
Jia Yan ◽  
Emma G. Hooper ◽  
Micah Gerhardt ◽  
...  


2019 ◽  
Vol 29 (8) ◽  
pp. 1125-1134 ◽  
Author(s):  
Qiong Wu ◽  
Xin Feng ◽  
Micah Gerhardt ◽  
Li Wang


2020 ◽  
pp. 1-17
Author(s):  
Xiaoqin Wang ◽  
Scott D. Blain ◽  
Jie Meng ◽  
Yuan Liu ◽  
Jiang Qiu


2021 ◽  
Author(s):  
Vanessa Villani

Background: Gene-environment (GXE) interaction models have demonstrated that DRD2, DAT1, COMT, and OXTR SNPs moderate parental factors (i.e., maternal depression, parenting) to predict outcomes related to emotion regulation (e.g., affective problems, attentional control). No studies have investigated the connections between maternal maltreatment history and infant dopamine and oxytocin gene variants as they relate to infant emotion regulation. The current study addresses these gaps, evaluating the interaction of selected genes as they interact with maternal history of maltreatment to predict infant emotion regulation. Method: I investigated five infant genotypes (DRD2, DAT1, COMT, OXTR rs53576, and OXTR rs2254298) as they interacted with maternal history of self-reported maltreatment to predict observed infant emotion regulation behaviours. Self-reported maternal depressive symptoms were covaried. Infant emotion regulation was observed in the context of a potent stressor. I assessed three potential models of interaction, diathesis-stress, differential sensitivity, or vantage sensitivity. Results: Analyses demonstrated that, over and above maternal depressive symptoms, DRD2 and COMT significantly interacted with self-reported maternal maltreatment scores in a ‘vantage sensitivity’ model and DAT1 significantly interacted with maternal maltreatment history in a ‘diathesis-stress’ model. A cumulative vantage sensitivity (CVS) index significantly interacted with maternal maltreatment history to predict emotion regulation scores, consistent with a vantage sensitivity model. Conclusions: Findings indicated that infants with the “vantage” DRD2 (A1+) and COMT (Met) alleles, when exposed to mothers with lesser histories of maltreatment, fair better in terms of regulation than their non-susceptible counterparts. Infants with the “risk” DAT1 (presence of the 9-repeat) allele, when exposed to a parent with a greater history of maltreatment, tended to fare worse in terms of regulation behaviours. These differences in genetic interaction models suggest that an adaptive variation in genetic vulnerability and vantage-sensitivity, across an infant’s genome, can increase the possibility for optimal self-regulation outcomes, whether the environment is favourable or less favourable (i.e., lower versus higher history of maternal maltreatment, respectively).



2018 ◽  
Vol 37 (4) ◽  
pp. 231-251 ◽  
Author(s):  
Matthew W. Southward ◽  
Erin M. Altenburger ◽  
Sara A. Moss ◽  
David R. Cregg ◽  
Jennifer S. Cheavens

We propose a model of healthy intentional emotion regulation that includes a large repertoire of adaptive strategies that one persists with despite initial negative feedback. One hundred forty-four undergraduates (average age = 19.20 years; 68% female, 79% Caucasian) completed a novel performance task indicating what they would think or do to feel better in response to eleven stressful vignettes. After their initial response, participants indicated four more times how they would respond if their previous strategy was not working. Raters categorized each response as an emotion regulation strategy and coded the adaptiveness of each strategy. Participants self-reported Neuroticism, Extraversion, Conscientiousness, Borderline Personality Disorder (BPD) symptoms, and depressive symptoms. We regressed each personality dimension and psychopathology symptom on our model of healthy emotion regulation. Neuroticism was negatively associated with adaptiveness and persistence. Extraversion was positively associated with adaptiveness. Conscientiousness was positively associated with repertoire, adaptiveness, and persistence, while BPD symptoms were negatively associated with all three variables. Depressive symptoms were negatively associated with persistence. These preliminary findings suggest that people with larger repertoires of more adaptive emotion regulation strategies who persist with these strategies despite initial negative feedback report less personality pathology and psychological distress.





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