Molecular profile of ultrastructure changes of the ligamentum flavum related to lumbar spinal canal stenosis

2019 ◽  
Vol 120 (7) ◽  
pp. 11716-11725 ◽  
Author(s):  
Eliezer Sidon ◽  
Shai S. Shemesh ◽  
Lisa Mor‐Yossef Moldovan ◽  
Yarden Wiesenfeld ◽  
Nissim Ohana ◽  
...  
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Molecular Profile ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Pathomechanism of Loss of Elasticity and Hypertrophy of Lumbar Ligamentum Flavum in Elderly Patients With Lumbar Spinal Canal Stenosis

Spine ◽  
2007 ◽  
Vol 32 (25) ◽  
pp. 2805-2811 ◽  
Author(s):  
Hirofumi Kosaka ◽  
Koichi Sairyo ◽  
Ashok Biyani ◽  
Douglas Leaman ◽  
Richard Yeasting ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

scholarly journals Decreased elastic fibers and increased proteoglycans in the ligamentum flavum of patients with lumbar spinal canal stenosis

2015 ◽  
Vol 34 (7) ◽  
pp. 1241-1247 ◽  
Author(s):  
Yutaka Yabe ◽  
Yoshihiro Hagiwara ◽  
Masahiro Tsuchiya ◽  
Masahito Honda ◽  
Kouki Hatori ◽  
...  
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Elastic Fibers ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

scholarly journals Leptin-induced inflammation by activating IL-6 expression contributes to the fibrosis and hypertrophy of ligamentum flavum in lumbar spinal canal stenosis

2018 ◽  
Vol 38 (2) ◽  
Author(s):  
Chao Sun ◽  
Zhen Wang ◽  
Ji-Wei Tian ◽  
Yun-Hao Wang
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Collagen I ◽  
Inflammatory Factor ◽  
Fibrosis Score ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

The ongoing chronic inflammation and subsequent fibrosis play an important role in ligamentum flavum (LF) fibrosis and hypertrophy in patients with lumbar spinal canal stenosis (LSCS). Leptin is a chronic inflammatory mediator and involved in the fibrotic process in multiple organ systems. The present study aimed to investigate the role of leptin in LF fibrosis and its related regulatory mechanisms. The LF specimens were obtained during the surgery from 12 patients with LSCS (LSCS group) and 12 control patients with lumbar disc herniation (LDH) group. The morphologic changes and fibrosis score of LF were assessed by Hematoxylin and eosin (H&E) and Masson’s trichrome staining respectively. The location and expression of leptin in LF tissues were determined. Then, the LF cells were cultured and exposed to recombinant human leptin (rhleptin). Collagen I and III were used as fibrosis markers and IL-6 was used as the inflammatory factor. As a result, the LF thickness and fibrosis score in the LSCS group were significantly higher than those in the LDH group (P<0.05). Leptin was detected in the hypertrophied LF and its expression was substantially increased in the LSCS group and positively correlated with LF thickness and fibrosis score (P<0.05). Moreover, our in vitro experiments revealed that rhleptin treated LF cells elevated the expression of collagen I and III. Finally, leptin administration induced IL-6 expression via nuclear factor-κB (NF-κB) pathway in LF cell (P<0.05). Our study demonstrated novel molecular events for leptin-induced inflammation in LF tissue by promoting IL-6 expression and thus might have potential implications for clarifying the mechanism underlying LF fibrosis and hypertrophy.

Apolipoprotein AI amyloid deposits in the ligamentum flavum in patients with lumbar spinal canal stenosis

Amyloid ◽  
2020 ◽  
pp. 1-6
Author(s):  
Masayoshi Tasaki ◽  
Masamitsu Okada ◽  
Akihiro Yanagisawa ◽  
Toshiya Nomura ◽  
Hiroaki Matsushita ◽  
...  
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Apolipoprotein Ai ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Amyloid Deposits ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Collagen profiling of ligamentum flavum in patients with lumbar spinal canal stenosis

2020 ◽  
Author(s):  
Hiroki Takeda ◽  
Sota Nagai ◽  
Daiki Ikeda ◽  
Shinjiro Kaneko ◽  
Takashi Tsuji ◽  
...  
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Myofibroblasts are increased in the dorsal layer of the hypertrophic ligamentum flavum in lumbar spinal canal stenosis

2021 ◽  
Author(s):  
Fumio Hayashi ◽  
Masatoshi Morimoto ◽  
Kosaku Higashino ◽  
Yuichiro Goda ◽  
Nori Sato ◽  
...  
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Hypertrophied Ligamentum Flavum in Lumbar Spinal Canal Stenosis

Spine ◽  
1992 ◽  
Vol 17 (11) ◽  
pp. 1353-1360 ◽  
Author(s):  
Munehito Yoshida ◽  
Kinya Shima ◽  
Yasunori Taniguchi ◽  
Tetsuya Tamaki ◽  
Tomoyuki Tanaka
Keyword(s):  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Diabetes mellitus is associated with increased elastin fiber loss in ligamentum flavum of patients with lumbar spinal canal stenosis: results of a pilot histological study

2017 ◽  
Vol 27 (7) ◽  
pp. 1614-1622 ◽  
Author(s):  
Shai Shemesh ◽  
Eliezer Sidon ◽  
Efrat Kaisler ◽  
Dimitry Sheinis ◽  
Steven Velkes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Histological Study ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Elastin Fiber ◽  
Canal Stenosis ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal

Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus

2011 ◽  
Vol 16 (6) ◽  
pp. 785-790 ◽  
Author(s):  
Guanyu Cui ◽  
Yoshiteru Miyauchi ◽  
Naobumi Hosogane ◽  
Takashi Tsuji ◽  
Ken Ishii ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Matrix Metalloproteinase ◽  
Spinal Canal ◽  
Ligamentum Flavum ◽  
Spinal Canal Stenosis ◽  
Lumbar Spinal Canal Stenosis ◽  
Canal Stenosis ◽  
Matrix Metalloproteinase 13 ◽  
Lumbar Spinal Canal ◽  
Lumbar Spinal
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