Using the gini coefficient to measure the chemical diversity of small-molecule libraries

2016 ◽  
Vol 37 (22) ◽  
pp. 2091-2097 ◽  
Author(s):  
Iwona E. Weidlich ◽  
Igor V. Filippov
Keyword(s):  
Small Molecule ◽  
Gini Coefficient ◽  
Chemical Diversity ◽  
The Gini Coefficient ◽  
Small Molecule Libraries

Pentaerythritol and Its Congeners: Versatile Building Blocks for the Construction of Oligomeric Bioconjugates and Small Molecule Libraries on a Solid Support

2004 ◽  
Vol 8 (11) ◽  
pp. 977-992 ◽  
Author(s):  
Johanna Katajisto ◽  
Petri Heinonen ◽  
Harri Lonnberg
Keyword(s):  
Small Molecule ◽  
Building Blocks ◽  
Solid Support ◽  
Small Molecule Libraries

scholarly journals Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell

2021 ◽  
Vol 143 (7) ◽  
pp. 2751-2756
Author(s):  
Lars K. Petersen ◽  
Allan B. Christensen ◽  
Jacob Andersen ◽  
Charlotta G. Folkesson ◽  
Ole Kristensen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Living Cell ◽  
Small Molecule Libraries

scholarly journals Why We Should Use the Gini Coefficient to Assess Punctuated Equilibrium Theory

2021 ◽  
pp. 1-6
Author(s):  
Constantin Kaplaner ◽  
Yves Steinebach
Keyword(s):  
Policy Change ◽  
Gini Coefficient ◽  
Policy Making ◽  
Punctuated Equilibrium ◽  
Equilibrium Theory ◽  
Punctuated Equilibrium Theory ◽  
The Gini Coefficient ◽  
Precise Measure

Abstract Punctuated Equilibrium Theory posits that policy-making is generally characterized by long periods of stability that are interrupted by short periods of fundamental policy change. The literature converged on the measure of kurtosis and L-kurtosis to assess these change patterns. In this letter, we critically discuss these measures and propose the Gini coefficient as a (1) comparable, but (2) more intuitive, and (3) more precise measure of “punctuated” change patterns.

A simple way to calculate the Gini coefficient, and some implications

1997 ◽  
Vol 56 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Branko Milanovic
Keyword(s):  
Gini Coefficient ◽  
The Gini Coefficient

The Gini coefficient: Majority voting and social welfare

2014 ◽  
Vol 152 ◽  
pp. 214-223 ◽  
Author(s):  
Juan Gabriel Rodríguez ◽  
Rafael Salas
Keyword(s):  
Social Welfare ◽  
Gini Coefficient ◽  
Majority Voting ◽  
The Gini Coefficient

Towards drugging the ‘undruggable’: enhancing the scaffold diversity of synthetic small molecule screening collections using diversity-oriented synthesis

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Warren R.J.D. Galloway ◽  
David R. Spring
Keyword(s):  
Small Molecule ◽  
Structural Diversity ◽  
Library Size ◽  
Diversity Oriented Synthesis ◽  
Biological Targets ◽  
Small Molecule Screening ◽  
Chemistry Research ◽  
Large Numbers ◽  
Small Molecule Libraries ◽  
Scaffold Diversity

AbstractMedicinal chemistry research has traditionally focused upon a limited set of biological targets. Many other human disease-related targets have been termed ‘undruggable’ as they have proved largely impervious to modulation by small molecules. However, it is becoming increasingly evident that such targets can indeed be modulated; they are simply being challenged with the wrong types of molecules. Traditionally, screening libraries were composed of large numbers of structurally similar compounds. However, library size is not everything; the structural diversity of the library, which is largely dictated by the range of molecular scaffolds present, is crucial. Diversity-oriented synthesis (DOS) generates small molecule libraries with high levels of scaffold, and thus structural, diversity. Such collections should provide hits against a broad range of targets with high frequency, including ‘undruggable’ targets. Examples in the area of scaffold diversity generation taken from the author’s laboratories are given.

Equitable service by a facility: Minimizing the Gini coefficient

2009 ◽  
Vol 36 (12) ◽  
pp. 3240-3246 ◽  
Author(s):  
Tammy Drezner ◽  
Zvi Drezner ◽  
Jeffery Guyse
Keyword(s):  
Gini Coefficient ◽  
The Gini Coefficient
Sign in / Sign up

Export Citation Format

Share Document