Unraveling individual host–guest interactions in molecular recognition from first principles quantum mechanics: Insights into the nature of nicotinic acetylcholine receptor agonist binding

First Principles ◽

Receptor Agonist ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Individual Host

3P-085 Molecular recognition of barbiturate enantiomer in agonist binding site of nicotinic acetylcholine receptor(The 46th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri ◽

10.2142/biophys.48.s140_4 ◽

2008 ◽

Vol 48 (supplement) ◽

pp. S140

Author(s):

Masayuki Ozaki ◽

Tomoyoshi Seto

Keyword(s):

Molecular Recognition ◽

Binding Site ◽

Annual Meeting ◽

Acetylcholine Receptor ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Biophysical Society

Identification of Amino Acids in the Nicotinic Acetylcholine Receptor Agonist Binding Site and Ion Channel Photolabeled by 4-[(3-Trifluoromethyl)-3H-Diazirin-3-yl]Benzoylcholine, a Novel Photoaffinity Antagonist†

Biochemistry ◽

10.1021/bi0269815 ◽

2003 ◽

Vol 42 (2) ◽

pp. 271-283 ◽

Cited By ~ 14

Author(s):

David C. Chiara ◽

Jonathan C. Trinidad ◽

Dong Wang ◽

Michael R. Ziebell ◽

Deirdre Sullivan ◽

...

Keyword(s):

Amino Acids ◽

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Binding ◽

Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

Molecular Pharmacology ◽

10.1124/mol.106.026815 ◽

2006 ◽

Vol 70 (4) ◽

pp. 1255-1263 ◽

Cited By ~ 88

Author(s):

Masaru Shimomura ◽

Maiko Yokota ◽

Makoto Ihara ◽

Miki Akamatsu ◽

David B. Sattelle ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Binding ◽

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54504-x ◽

1991 ◽

Vol 266 (34) ◽

pp. 23354-23364

Author(s):

J.B. Cohen ◽

S.D. Sharp ◽

W.S. Liu

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Cation Binding ◽

Agonist Binding ◽

Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

Brain Research ◽

10.1016/s0006-8993(01)03028-1 ◽

2001 ◽

Vol 919 (1) ◽

pp. 166-168 ◽

Cited By ~ 3

Author(s):

Xu-Feng Zhang ◽

David G. McKenna ◽

Clark A. Briggs

Keyword(s):

Dorsal Root Ganglion ◽

Acetylcholine Receptor ◽

Dorsal Root ◽

Receptor Agonist ◽

Dorsal Root Ganglion Neurons ◽

Nicotinic Acetylcholine ◽

Ganglion Neurons

Protein-ligand interactions. 6 nicotinic acetylcholine receptor agonist activity of isoquinoline alkaloids

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00429-5 ◽

1996 ◽

Vol 6 (23) ◽

pp. 2801-2806 ◽

Cited By ~ 5

Author(s):

C.G. Whiteley ◽

S. Daya

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Activity ◽

Isoquinoline Alkaloids ◽

Nicotinic Acetylcholine ◽

Protein Ligand Interactions ◽

Ligand Interactions

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Cited By ~ 40

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Cited By ~ 5

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory

QJM ◽

10.1093/qjmed/hcx014 ◽

2017 ◽

pp. hcx014 ◽

Cited By ~ 2

Author(s):

Xi Yang ◽

Caiqi Zhao ◽

Xiu Chen ◽

Lubin Jiang ◽

Xiao Su

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Nicotinic Acetylcholine ◽

Α7 Nachr ◽

Anti Inflammatory

Efficacy and Safety of the α7-Nicotinic Acetylcholine Receptor Agonist ABT-126 in the Treatment of Cognitive Impairment Associated With Schizophrenia

The Journal of Clinical Psychiatry ◽

10.4088/jcp.16m11162 ◽

2018 ◽

Vol 79 (3) ◽

Cited By ~ 3

Author(s):

George M. Haig ◽

Deli Wang ◽

Jun Zhao ◽

Ahmed A. Othman ◽

Earle E. Bain

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Efficacy And Safety ◽

Α7 Nicotinic Acetylcholine Receptor ◽