scholarly journals Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation

2018 ◽  
Vol 104 (3) ◽  
pp. 447-459 ◽  
Author(s):  
Madelyn H. Miller ◽  
Michael G. Shehat ◽  
Karel P. Alcedo ◽  
Lina P. Spinel ◽  
Julia Soulakova ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Airway Inflammation ◽  
Dust Mite

scholarly journals Allergin-1 Immunoreceptor Suppresses House Dust Mite–Induced Allergic Airway Inflammation

2020 ◽  
Vol 204 (4) ◽  
pp. 753-762 ◽  
Author(s):  
Haruka Miki ◽  
Satoko Tahara-Hanaoka ◽  
Mariana Silva Almeida ◽  
Kaori Hitomi ◽  
Shohei Shibagaki ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Airway Inflammation ◽  
Dust Mite

scholarly journals IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite–induced asthma models

2017 ◽  
Vol 214 (10) ◽  
pp. 3037-3050 ◽  
Author(s):  
Takashi Ito ◽  
Koichi Hirose ◽  
Aiko Saku ◽  
Kenta Kono ◽  
Hiroaki Takatori ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Cytokine Production ◽  
Allergic Airway Inflammation ◽  
Lung Epithelial Cells ◽  
Intratracheal Administration ◽  
Lung Epithelial ◽  
Dust Mite

Previous studies have shown that IL-22, one of the Th17 cell–related cytokines, plays multiple roles in regulating allergic airway inflammation caused by antigen-specific Th2 cells; however, the underlying mechanism remains unclear. Here, we show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite (HDM) extract, a representative allergen, were exacerbated in IL-22-deficient mice. We also found that IL-22 induces Reg3γ production from lung epithelial cells through STAT3 activation and that neutralization of Reg3γ significantly exacerbates HDM-induced eosinophilic airway inflammation and Th2 cytokine induction. Moreover, exostatin-like 3 (EXTL3), a functional Reg3γ binding protein, is expressed in lung epithelial cells, and intratracheal administration of recombinant Reg3γ suppresses HDM-induced thymic stromal lymphopoietin and IL-33 expression and accumulation of type 2 innate lymphoid cells in the lung. Collectively, these results suggest that IL-22 induces Reg3γ production from lung epithelial cells and inhibits the development of HDM-induced allergic airway inflammation, possibly by inhibiting cytokine production from lung epithelial cells.

scholarly journals β2 adrenergic agonist attenuates house dust mite-induced allergic airway inflammation through dendritic cells

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Go Kato ◽  
Koichiro Takahashi ◽  
Hiroki Tashiro ◽  
Keigo Kurata ◽  
Hideharu Shirai ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Airway Inflammation ◽  
Adrenergic Agonist ◽  
Dust Mite

House Dust Mite Interactions with Airway Epithelium: Role in Allergic Airway Inflammation

2013 ◽  
Vol 13 (3) ◽  
pp. 262-270 ◽  
Author(s):  
Vivek D. Gandhi ◽  
Courtney Davidson ◽  
Muhammad Asaduzzaman ◽  
Drew Nahirney ◽  
Harissios Vliagoftis
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Epithelium ◽  
Allergic Airway Inflammation ◽  
Dust Mite
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