A randomized controlled trial on the impact of healing time on wound healing following ridge preservation using a 70%/30% combination of mineralized and demineralized freeze‐dried bone allograft

2020 ◽  
Vol 91 (10) ◽  
pp. 1256-1263
Author(s):  
Aaron C. Nelson ◽  
Brian L. Mealey
Keyword(s):  
Wound Healing ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Bone Allograft ◽  
Healing Time ◽  
Ridge Preservation ◽  
Randomized Controlled ◽  
Freeze Dried ◽  
The Impact

scholarly journals The The impact of a muscle pump activator on incisional wound healing compared to standard stockings and compression devices in kidney and kidney-pancreas transplant recipients: A randomized controlled trial

2019 ◽  
Vol 13 (11) ◽  
Author(s):  
Shahid Aquil ◽  
Hemant Sharma ◽  
Bijad Alharbi ◽  
Katharine Pacoli ◽  
Patrick P. Luke ◽  
...  
Keyword(s):  
Wound Healing ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Wound Infections ◽  
Transplant Recipients ◽  
Muscle Pump ◽  
Randomized Controlled ◽  
Surgery Patient ◽  
Complex Wound ◽  
The Impact

Introduction: We aimed to evaluate the impact of thrombo-embolic-deterrent + intermittent pneumatic compression (TED + IPC) vs. muscle pump activator (MPA) on incisional wound healing in kidney and simultaneous pancreas- kidney (SPK) transplant recipients. Methods: We conducted a single-centre, randomized controlled trial in which 104 patients (kidney n=94; SPK n=10) were randomly assigned to wear TED + IPC (n= 52) or MPA (n=52) for the first six days following surgery. Patient demographics, postoperative outcomes, and incisional wound images were taken using a HIPAA-compliant application on postoperative days (POD) 3, 5, and 30, and assessed using the validated Southampton Wound Care Score. Results: There were no demographic differences between the groups. The MPA group had a significant improvement in wound healing on POD 3 (p=0.04) that persisted until POD 5 (p=0.0003). At POD 30, both groups were similar in wound healing outcomes (p=0.51). Bayesian inferential analysis revealed that the use of TED + IPC following transplantation had inferior outcomes compared to the use of MPA with sequential moderate evidence. The rate of complex wound infections was significantly greater in the TED + IPC group compared to the MPA group (29% vs. 12%, respectively; p=0.03). Patients were more satisfied with the use of a MPA device than TED + IPC. No major complications were encountered in either group. Conclusions: The use of a MPA device in the immediate postoperative period leads to a significant improvement in immediate and early wound healing, and decreased number of complex wound infections following kidney and SPK transplantation compared to standard TED + IPC therapy. Patients were more satisfied with the use of a MPA device than TED + IPC.

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