Surgical resection of high‐grade nonfunctional pancreatic neuroendocrine carcinoma is associated with improved survival

2021 ◽  
Author(s):  
Jerry Jiang ◽  
Joon Park ◽  
Stephanie Kim ◽  
Amanda Daan ◽  
Timothy Donahue ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Pancreatic Neuroendocrine Carcinoma

Intraductal Tubulopapillary Neoplasm of the Pancreas Masquerading as Pancreatic Neuroendocrine Carcinoma: Review of the Literature with a Case Report

2016 ◽  
Vol 60 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Deepika Savant ◽  
Lili Lee ◽  
Kasturi Das
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
High Grade ◽  
Cytologic Diagnosis ◽  
Ki 67 ◽  
Tubule Formation ◽  
Distal Pancreatic Resection ◽  
Intraductal Tubulopapillary Neoplasm ◽  
Pancreatic Neuroendocrine Carcinoma

Background: Intraductal tubulopapillary neoplasm of the pancreas (ITPN) is a rare tumor which was first described in 2009. We report a case with cytologic and histologic findings and discuss the pitfalls in diagnosing this entity on cytology. Case: An 82-year-old female presented with a pancreatic body mass measuring 3.3 cm. Endoscopic ultrasound-guided fine-needle aspiration showed cells in cohesive clusters with high-grade nuclear atypia. Immunohistochemistry (IHC) showed the neoplastic cells to be positive for CK19, CD56 and chromogranin (focal). Ki-67 was high at 50-60%, and chymotrypsin was negative. On the basis of this pattern of staining, the cytologic diagnosis rendered was ‘favors high-grade neuroendocrine carcinoma'. Distal pancreatic resection revealed a cystic 4-cm mass. Histologically, the tumor was seen arising from the duct with a solid growth pattern, tubule formation and papillary structures. IHC showed the tumor to be negative for chromogranin, synaptophysin, CD56, trypsin and chymotrypsin. The Ki-67 index was 70%. The final diagnosis was noninvasive ITPN. Conclusion: We review the literature and discuss the cytomorphologic features and IHC patterns characteristic of this new entity on cytology material in addition to the pitfalls of the cytologic diagnosis.

scholarly journals Surgical resection of the primary tumor leads to prolonged survival in metastatic pancreatic neuroendocrine carcinoma

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Tingting Feng ◽  
Wangxia Lv ◽  
Meiqin Yuan ◽  
Zhong Shi ◽  
Haijun Zhong ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Neuroendocrine Carcinoma ◽  
Primary Tumor ◽  
Prolonged Survival ◽  
Pancreatic Neuroendocrine Carcinoma

scholarly journals Unexpected Long term Survival after Surgical Resection for Non-functioning Pancreatic Neuroendocrine Carcinoma with Cutaneous Metastasis

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S433-S434
Author(s):  
Woo Young Shin ◽  
Jeong-Sik Choi ◽  
Keon Young Lee ◽  
Seung Ik Ahn
Keyword(s):  
Surgical Resection ◽  
Neuroendocrine Carcinoma ◽  
Cutaneous Metastasis ◽  
Term Survival ◽  
Long Term Survival ◽  
Pancreatic Neuroendocrine Carcinoma

Treatment of High-Grade Metastatic Pancreatic Neuroendocrine Carcinoma with FOLFIRINOX

2015 ◽  
Vol 46 (2) ◽  
pp. 166-169 ◽  
Author(s):  
Jason Zhu ◽  
Jonathan R. Strosberg ◽  
Evan Dropkin ◽  
John H. Strickler
Keyword(s):  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Pancreatic Neuroendocrine Carcinoma

scholarly journals Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

2015 ◽  
Vol 23 (5) ◽  
pp. 1721-1728 ◽  
Author(s):  
Sven-Petter Haugvik ◽  
Eva Tiensuu Janson ◽  
Pia Österlund ◽  
Seppo W. Langer ◽  
Ragnhild Sørum Falk ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Comparative Study ◽  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Pancreatic Neuroendocrine Carcinoma

Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape

2016 ◽  
Vol 18 (5) ◽  
Author(s):  
Sven-Petter Haugvik ◽  
Daniel Kaemmerer ◽  
Sebastien Gaujoux ◽  
Knut Jørgen Labori ◽  
Caroline Sophie Verbeke ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Neuroendocrine Carcinoma ◽  
High Grade ◽  
Pancreatic Neuroendocrine Carcinoma

scholarly journals Prolonged Clinical Benefit of Everolimus Therapy in the Management of High-Grade Pancreatic Neuroendocrine Carcinoma

2013 ◽  
Vol 6 (2) ◽  
pp. 441-449 ◽  
Author(s):  
Paula J. Fonseca ◽  
Esther Uriol ◽  
José A. Galván ◽  
Carlos Álvarez ◽  
Quionia Pérez ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Clinical Benefit ◽  
High Grade ◽  
Pancreatic Neuroendocrine Carcinoma

scholarly journals Surgical resection for clinical stage I high-grade neuroendocrine carcinoma of the lung

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Eisuke Mochizuki ◽  
Shun Matsuura ◽  
Kyohei Oishi ◽  
Koichi Miyashita ◽  
Koshiro Ichijyo ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Neuroendocrine Carcinoma ◽  
Clinical Stage ◽  
Stage I ◽  
High Grade
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