scholarly journals What is the role of intralesional corticosteroid injections for keloids before considering surgery?

2015 ◽  
Vol 126 (3) ◽  
pp. 549-550 ◽  
Author(s):  
Louis Insalaco ◽  
Sarah Saxon ◽  
Jeffrey H. Spiegel
Keyword(s):  
Intralesional Corticosteroid ◽  
Corticosteroid Injections

ROLE OF PHENERGAN IN ABNORMAL SCARS AND KELOIDS

2004 ◽  
Vol 12 (04) ◽  
pp. 471-482
Author(s):  
J. VENUGOPAL ◽  
V. JAYARAMAN ◽  
MARY BABU ◽  
S. RAMAKRISHNA
Keyword(s):  
Dna Synthesis ◽  
Hypertrophic Scar ◽  
Skin Fibroblast ◽  
Collagen Synthesis ◽  
Normal Skin ◽  
Compression Therapy ◽  
Matrix Proteins ◽  
Intralesional Corticosteroid ◽  
Normal Skin Fibroblast

Hypertrophic scar and keloids have affected patients and frustrated physicians for centuries. Hypertrophic scar (HSc) and keloids are a major problem for patients who survive extensive thermal and traumatic skin injuries. HSc and other fibroproliferative disorders are associated with excessive accumulation of collagen and extracellular matrix proteins due to an imbalance between synthesis and degradation. The therapeutic management of hypertrophic scars and keloids include occlusive dressings, compression therapy, intralesional corticosteroid injections, cryosurgery, excision, radiation therapy, laser therapy, interferon therapy and other promising lesser known therapies directed at collagen synthesis. In this study we investigated the effect of phenergan (promethazine hydrochloride) as one of the most potent histamine antagonists on cell proliferation, DNA synthesis and collagen production in fibroblast isolated from human post burn hypertrophic scar, keloids and normal skin. The proliferation of normal skin fibroblast was slightly decreased but hypertrophic scar and keloids showed significant (p<0.001) level of decrease after 72 hours of phenergan (750 μM) treatment. The results of DNA synthesis also significantly (p<0.001) decreased in hypertrophic scar and keloid fibroblasts. Phenergan (1.5 mM) decreased the collagen synthesis upto 61% and 66% in HSc and keloids in comparison to normal skin fibroblast, which showed reduction of 38% after 72 hours. Improved understanding of such regulatory mechanisms may eventually be of therapeutic significance in the control of hypertrophic scar and keloids.

Intranasal Steroids in Rhinology: The Changing Role of Intraturbinal Injection

1994 ◽  
Vol 73 (4) ◽  
pp. 242-246 ◽  
Author(s):  
Richard L. Mabry
Keyword(s):  
Topical Corticosteroid ◽  
Visual Loss ◽  
Steroid Injection ◽  
Large Series ◽  
Nasal Sprays ◽  
Intranasal Steroids ◽  
Nasal Steroid ◽  
Changing Role ◽  
Corticosteroid Injections

Intraturbinal injection of repository corticosteroid has been widely used by otolaryngologists for over four decades. The potential for visual loss when retinal embolization or vasospasm complicate this procedure and the introduction of topical nasal steroid preparations have gradually reduced its usage and reshaped the role of intraturbinal steroid injection in the management of a variety of rhinologic disorders. A review by the author of twenty-five years’ experience, including over thirteen thousand intraturbinal corticosteroid injections, shows no visual complications in this large series. However, a decline in the use of this procedure was noted, possibly influenced by several factors. Appropriate roles for intraturbinal steroid injection and topical corticosteroid nasal sprays are suggested.

scholarly journals Adjunct Treatment of Recalcitrant Hand Plaques in Nephrogenic Systemic Fibrosis After Imatinib Therapy

2019 ◽  
Vol 3 (6) ◽  
pp. 438-442
Author(s):  
James Foshee ◽  
Thomas Griffin ◽  
Kristin Cam ◽  
Michael Rivlin ◽  
Matthew Keller
Keyword(s):  
Nephrogenic Systemic Fibrosis ◽  
Functional Limitation ◽  
Lower Extremities ◽  
Functional Improvement ◽  
Adjunct Treatment ◽  
Joint Contractures ◽  
Intralesional Corticosteroid ◽  
Initial Improvement ◽  
Effective Adjunct ◽  
Corticosteroid Injections

Nephrogenic systemic fibrosis (NSF) is a sclerotic disorder presenting with painful indurated plaques and skin thickening involving the trunk and extremities, which can lead to tethering and joint contractures.  NSF most commonly affects patients with renal insufficiency who have been exposed to gadolinium. We present a case of NSF involving the bilateral hands, knees, and lower extremities developing over 10 years after gadolinium exposure.  Initial improvement was noted in the lower extremities after initiation of imatinib mesylate therapy, but recalcitrant, thickened hand plaques caused persistent pain and functional limitation. Adjunct intralesional corticosteroid injections produced durable softening of the recalcitrant lesions with considerable functional improvement in hand mobility. Based on our experience, intralesional corticosteroid injections appear to be an effective adjunct treatment in patients with incomplete response to anti-fibrotic therapies.

scholarly journals Successful Treatment of Kasabach-Merritt Phenomenon With Intralesional Corticosteroid Injections

2012 ◽  
Vol 69 (6) ◽  
pp. 627-632 ◽  
Author(s):  
Jian-Jr Lee ◽  
Li-Ying Lin ◽  
Shun-Wen Hsieh ◽  
Ting-An Chang ◽  
Shiann-Tarng Jou ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Intralesional Corticosteroid ◽  
Corticosteroid Injections

scholarly journals Hidradenitis suppurativa with SAPHO syndrome maintained effectively with adalimumab, methotrexate, and intralesional corticosteroid injections

2018 ◽  
Vol 6 ◽  
pp. 2050313X1877872 ◽  
Author(s):  
Erika L Crowley ◽  
Ashley O’Toole ◽  
Melinda J Gooderham
Keyword(s):  
Hidradenitis Suppurativa ◽  
Relevant Literature ◽  
Skin Inflammation ◽  
Lifestyle Changes ◽  
Definitive Treatment ◽  
Intralesional Corticosteroid ◽  
Treatment Plans ◽  
Bone Inflammation ◽  
Pain Improvement ◽  
Corticosteroid Injections

Introduction: Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare. Methods/Results: This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature. Initial oral and topical antibiotics had little effect. Intralesional corticosteroid injections were effective for localized inflammatory lesions but insufficient for hidradenitis suppurativa control. Adalimumab initiation and local excision of a persistent HS lesion led to stabilization. Adalimumab provided dramatic back pain improvement. Synovitis, acne, pustulosis, hyperostosis, osteitis was diagnosed; adalimumab continuation with subsequent methotrexate addition resulted in hidradenitis suppurativa-synovitis, acne, pustulosis, hyperostosis, osteitis control. Conclusions: Literature regarding comorbid hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome therapy is scarce but growing. Adalimumab, methotrexate, intralesional corticosteroid, and lifestyle changes successfully maintained a severe hidradenitis suppurativa–synovitis, acne, pustulosis, hyperostosis, osteitis–syndrome case. Further studies beyond a case-based review could yield more definitive treatment plans.

scholarly journals Delineating the Role of Multiple Intraarticular Corticosteroid Injections in the Management of Juvenile Idiopathic Arthritis in the Biologic Era

2013 ◽  
Vol 65 (7) ◽  
pp. 1112-1120 ◽  
Author(s):  
Charalampia Papadopoulou ◽  
Mikhail Kostik ◽  
Maria Isabel Gonzalez-Fernandez ◽  
Marek Bohm ◽  
Juan Carlos Nieto-Gonzalez ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Corticosteroid Injections
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