Successful Treatment of Kasabach-Merritt Phenomenon With Intralesional Corticosteroid Injections

Nephrogenic systemic fibrosis (NSF) is a sclerotic disorder presenting with painful indurated plaques and skin thickening involving the trunk and extremities, which can lead to tethering and joint contractures. NSF most commonly affects patients with renal insufficiency who have been exposed to gadolinium. We present a case of NSF involving the bilateral hands, knees, and lower extremities developing over 10 years after gadolinium exposure. Initial improvement was noted in the lower extremities after initiation of imatinib mesylate therapy, but recalcitrant, thickened hand plaques caused persistent pain and functional limitation. Adjunct intralesional corticosteroid injections produced durable softening of the recalcitrant lesions with considerable functional improvement in hand mobility. Based on our experience, intralesional corticosteroid injections appear to be an effective adjunct treatment in patients with incomplete response to anti-fibrotic therapies.

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Relapse in Alopecia Totalis after Successful Treatment with Intralesional Corticosteroid and Oral Immunomodulator

Journal of Skin and Stem Cell ◽

10.5812/jssc.104841 ◽

2020 ◽

Vol 7 (1) ◽

Author(s):

Lili Legiawati ◽

Lidwina Anissa

Keyword(s):

Successful Treatment ◽

Hair Loss ◽

Light Emitting Diode ◽

Inosine Pranobex ◽

Light Emitting ◽

Dermatological Examination ◽

Intralesional Corticosteroid ◽

Long Term Follow Up ◽

Topical Minoxidil ◽

One Year

Introduction: Alopecia areata (AA) is a chronic, recurrent, and non-scarring condition resulting in hair loss, which may affect all hair-bearing areas. There are three clinical patterns: patch AA, alopecia totalis, and alopecia universalis. Patients may show spontaneous recovery or respond well to treatment, but the disease may follow a course of relapse. Case Presentation: We report a case of recurrent alopecia totalis following successful treatment six years prior to the current visit. A 19-year-old female of Asian descent was admitted to our clinic due to recurrent hair loss in the last three months. Six years prior, she was diagnosed with alopecia totalis. After four years in remission, she started to have patchy hair loss. Dermatological examination revealed six nummular well-defined alopecia patches all over her parietal, temporal, and occipital scalp. She was treated with triamcinolone injection and light-emitting diode (LED). Additionally, topical minoxidil and hydrocortisone butyrate scalp solution were applied daily. Oral Inosine pranobex was administered twice a week. One year after the first re-administration of the therapy, complete remission was achieved. Conclusions: Relapse in AA is common. Patients should be informed during education and counseling. Long term follow-up is essential in managing patients with AA.

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12712 Use of local anesthetic for intralesional corticosteroid injections: A double-blinded randomized controlled trial

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2020.06.527 ◽

2020 ◽

Vol 83 (6) ◽

pp. AB110

Author(s):

Danny Zakria ◽

J. Randall Patrinely ◽

Anna K. Dewan ◽

Sharon E. Albers ◽

Lee Wheless ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Local Anesthetic ◽

Controlled Trial ◽

Randomized Controlled ◽

Intralesional Corticosteroid ◽

Double Blinded ◽

Corticosteroid Injections

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TREATMENT OF GIANT CELL GRANULOMA WITH INTRALESIONAL CORTICOSTEROID INJECTIONS: A CASE REPORT

Journal of Istanbul University Faculty of Dentistry ◽

10.17096/jiufd.88120 ◽

2015 ◽

Vol 49 (3) ◽

pp. 45

Author(s):

Özlem Filiz Bayar ◽

Gülsüm AK

Keyword(s):

Case Report ◽

Giant Cell ◽

Giant Cell Granuloma ◽

Intralesional Corticosteroid ◽

Corticosteroid Injections

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Hidradenitis suppurativa with SAPHO syndrome maintained effectively with adalimumab, methotrexate, and intralesional corticosteroid injections

SAGE Open Medical Case Reports ◽

10.1177/2050313x18778723 ◽

2018 ◽

Vol 6 ◽

pp. 2050313X1877872 ◽

Cited By ~ 4

Author(s):

Erika L Crowley ◽

Ashley O’Toole ◽

Melinda J Gooderham

Keyword(s):

Hidradenitis Suppurativa ◽

Relevant Literature ◽

Skin Inflammation ◽

Lifestyle Changes ◽

Definitive Treatment ◽

Intralesional Corticosteroid ◽

Treatment Plans ◽

Bone Inflammation ◽

Pain Improvement ◽

Corticosteroid Injections

Introduction: Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare. Methods/Results: This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature. Initial oral and topical antibiotics had little effect. Intralesional corticosteroid injections were effective for localized inflammatory lesions but insufficient for hidradenitis suppurativa control. Adalimumab initiation and local excision of a persistent HS lesion led to stabilization. Adalimumab provided dramatic back pain improvement. Synovitis, acne, pustulosis, hyperostosis, osteitis was diagnosed; adalimumab continuation with subsequent methotrexate addition resulted in hidradenitis suppurativa-synovitis, acne, pustulosis, hyperostosis, osteitis control. Conclusions: Literature regarding comorbid hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome therapy is scarce but growing. Adalimumab, methotrexate, intralesional corticosteroid, and lifestyle changes successfully maintained a severe hidradenitis suppurativa–synovitis, acne, pustulosis, hyperostosis, osteitis–syndrome case. Further studies beyond a case-based review could yield more definitive treatment plans.

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