scholarly journals Intrahepatic recurrence of hepatocellular carcinoma 13 years after orthotopic liver transplantation for hepatitis C-related cirrhosis with occult hepatocellular carcinoma: A case report

2012 ◽  
Vol 18 (5) ◽  
pp. 612-614
Author(s):  
Andrew C. Nelson ◽  
Jose Jessurun ◽  
Randolph K. Peterson ◽  
Stefan E. Pambuccian
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Case Report ◽  
Hepatitis C ◽  
Orthotopic Liver Transplantation ◽  
Intrahepatic Recurrence

scholarly journals Hepatocellular carcinoma in patients undergoing orthotopic liver transplantation: radiological findings with anatomopathological correlation in Brazil

2006 ◽  
Vol 43 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Antônio Carlos Maciel ◽  
Carlos Thadeu Cerski ◽  
Roger Klein Moreira ◽  
Vinicius Labrea Resende ◽  
Maria Lúcia Zanotelli ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Orthotopic Liver Transplantation ◽  
Imaging Techniques ◽  
Arterial Phase ◽  
Hepatitis C Virus Infection ◽  
Cirrhotic Patients

BACKGROUND: Hepatocellular carcinoma is one of the most common malignant tumors worldwide. Imaging techniques, specially computed tomography and ultrasound, are among the most useful diagnostic tools, although the accuracy of these methods may have a significant variability. AIMS: To determine the prevalence of hepatocellular carcinoma in cirrhotic patients undergoing orthotopic liver transplantation at "Santa Casa de Misericórdia" of Porto Alegre, RS, Brazil; to estimate the sensitivity of computed tomography and ultrasound in pretransplantation detection of hepatocellular carcinoma in this population; to correlate the radiological characteristics with anatomopathological findings. MATERIALS AND METHODS: Retrospective prevalence study. Population: adult, cirrhotic patients undergoing orthotopic liver transplantation from January 1990 to July 2003. Among the 292 transplanted patients, 31 cases of hepatocellular carcinoma were diagnosed, of which 29 were included in the study. Tumor characteristics in both ultrasound and computed tomography were compared to those observed in anatomopathological examination. RESULTS: Prevalence of hepatitis C virus infection among patients with diagnosis of hepatocellular carcinoma was 93.5%, and the prevalence of hepatocellular carcinoma among transplanted patients was 10.6%. The overall sensitivity of the imaging techniques was 70.3% for computed tomography and 72% for ultrasound. CONCLUSION: The prevalence of hepatocellular carcinoma at our institution, as well as the sensitivity of both ultrasound and computed tomography to detect such tumors at pretransplantation screening were similar to those found by other authors, while the prevalence of hepatitis C virus infection, the most common etiological agent for liver disease in our patients, is one of the highest ever reported in literature. Factors influencing hepatocellular carcinoma detection rates were: time from examination to liver transplantation; acquisition of computed tomography images during arterial phase; lesion size. Arterial phase proved to be the most useful part of computed tomography examination in this study.

Hepatocellular Carcinoma Complicating Recurrent Hepatitis C after Liver Transplantation - A Case Report

2012 ◽  
Vol 107 ◽  
pp. S429
Author(s):  
Abhijeet Waghray ◽  
Robert OʼShea ◽  
Narayanan K.V. Menon
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Case Report ◽  
Hepatitis C ◽  
Recurrent Hepatitis ◽  
Recurrent Hepatitis C

scholarly journals Outcome of orthotopic liver transplantation in patients with haemophilia

Gut ◽  
1998 ◽  
Vol 42 (5) ◽  
pp. 744-749 ◽  
Author(s):  
F H Gordon ◽  
P K Mistry ◽  
C A Sabin ◽  
C A Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Orthotopic Liver Transplantation ◽  
Clotting Factor ◽  
Bleeding Complications ◽  
Clotting Factors ◽  
Post Transplant

Background—Many patients with haemophilia have developed cirrhosis or hepatocellular carcinoma due to transfusion acquired chronic viral hepatitis.Aims—To assess the long term outcome of all haemophilic patients reported to have undergone orthotopic liver transplantation.Methods—Transplant centres of patients identified by medical database search were contacted and survival data assessed by Kaplan-Meier analysis.Results—Twenty six haemophilic men (median age 46 years, range 5–63 years) underwent orthotopic liver transplantation in 16 centres between 1982 and 1996. Indications for transplantation were hepatitis C cirrhosis (69%), hepatitis B with or without C cirrhosis (15%), viral hepatitis related hepatocellular carcinoma (12%), and biliary atresia (4%). Six patients (23%) were infected with human immunodeficiency virus (HIV). Postoperatively, the median time to normal clotting factor levels was 24 hours (range 0–48 hours) and exogenous clotting factors were stopped at a median of 24 hours (range 0–480 hours). Four patients (15%) had bleeding complications. The one and three year survival of HIV positive recipients (67% and 23%) was significantly poorer (p=0.0003) than that of HIV negative recipients (90% and 83%). Coagulopathy was cured in all patients surviving more than 12 days post-transplant. Six of the 20 patients (30%) with hepatitis C cirrhosis pretransplant had evidence of disease recurrence at a mean of nine months post-transplant.Conclusions—Hepatitis C cirrhosis is the most common indication for orthotopic liver transplantation in patients with haemophilia. Transplantation results in long term cure of haemophilia but may be complicated by the effects of HIV infection or recurrent viral hepatitis.

A patient with hepatitis C-related liver cirrhosis and hepatocellular carcinoma who was cured with an orthotopic liver transplantation and interferon therapy

2003 ◽  
Vol 38 (6) ◽  
pp. 598-602 ◽  
Author(s):  
Minoru Shibata ◽  
Katsuhiko Yanaga ◽  
Toshio Morizane ◽  
Tatsuro Yanagawa ◽  
Masami Hirakawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Orthotopic Liver Transplantation ◽  
Interferon Therapy

scholarly journals Liver transplantation in a patient with hepatitis B, C and D coinfection associated with hepatocellular carcinoma: a management strategy for a rare condition. Case report

2015 ◽  
Vol 133 (6) ◽  
pp. 525-530 ◽  
Author(s):  
Lucas Carvalho Dantas ◽  
Tércio Genzini ◽  
Marcelo Perosa de Miranda ◽  
Regina Gomes dos Santos ◽  
Nilton Ghiotti de Siqueira ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Case Report ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Antiviral Therapy ◽  
Rare Condition ◽  
Hepatitis C Infection ◽  
Hepatitis D ◽  
Before And After

CONTEXT: Orthotopic liver transplantation (OLT) is the treatment of choice for end-stage liver disease. Cirrhosis due to hepatitis C infection is the leading indication for liver transplantation worldwide. However, patients who are given transplants because of viral liver diseases often present clinical coinfections, including hepatitis B together with hepatitis D. Currently, different strategies exist for patient management before and after liver transplantation, and these are based on different protocols developed by the specialized transplantation centers. CASE REPORT: We present a rare case of a 58-year-old man with chronic hepatitis B, C and D coinfection. The patient developed cirrhosis and hepatocellular carcinoma. His treatment comprised antiviral therapy for the three viruses and OLT. The patient's outcome was satisfactory. CONCLUSION: OLT, in association with antiviral therapy using entecavir, which was administered before and after transplantation, was effective for sustained clearance of the hepatitis B and D viruses. A recurrence of hepatitis C infection after transplantation responded successfully to standard treatment comprising peginterferon alfa-2A and ribavirin.

Auxiliary partial orthotopic liver transplantation in the treatment of acute liver failure: A case report

2004 ◽  
Vol 36 (8) ◽  
pp. 2228-2229 ◽  
Author(s):  
D.S. Lee ◽  
J.G. Woo ◽  
H.H. Lee ◽  
K.W. Lee ◽  
J.W. Joh ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Orthotopic Liver Transplantation
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