Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia

2015 ◽  
Vol 30 (10) ◽  
pp. 1422-1426 ◽  
Author(s):  
Zsuzsanna Aschermann ◽  
Gabor Perlaki ◽  
Gergely Orsi ◽  
Szilvia Anett Nagy ◽  
Andrea Horvath ◽  
...  
Keyword(s):  
Cervical Dystonia ◽  
Quantitative Assessment ◽  
Brain Iron

Quantitative assessment of brain iron by R2* relaxometry in patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis

2009 ◽  
Vol 15 (9) ◽  
pp. 1048-1054 ◽  
Author(s):  
M Khalil ◽  
C Enzinger ◽  
C Langkammer ◽  
M Tscherner ◽  
M Wallner-Blazek ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Basal Ganglia ◽  
Quantitative Assessment ◽  
Disease Duration ◽  
Clinically Isolated Syndrome ◽  
Iron Accumulation ◽  
Iron Deposition ◽  
Relaxation Rates ◽  
Brain Iron ◽  
Relapsing Remitting

Background Increased iron deposition has been implicated in the pathophysiology of multiple sclerosis (MS), based on visual analysis of signal reduction on T2-weighted images. R2* relaxometry allows to assess brain iron accumulation quantitatively. Objective To investigate regional brain iron deposition in patients with a clinically isolated syndrome (CIS) or relapsing–remitting MS (RRMS) and its associations with demographical, clinical, and conventional magnetic resonance imaging (MRI) parameters. Methods We studied 69 patients (CIS, n = 32; RRMS, n = 37) with 3T MRI and analyzed regional R2* relaxation rates and their correlations with age, disease duration, disability, T2 lesion load, and normalized brain volumes. Results Basal ganglia R2* relaxation rates increased in parallel with age ( r = 0.3–0.6; P < 0.01) and were significantly higher in RRMS than in CIS ( P < 0.05). Using multivariate linear regression analysis, the rate of putaminal iron deposition was independently predicted by the patients’ age, disease duration, and gray matter atrophy. Conclusions Quantitative assessment by R2* relaxometry suggests increased iron deposition in the basal ganglia of MS patients, which is associated with disease duration and brain atrophy. This technique together with long-term follow-up thus appears suited to clarify whether regional iron accumulation contributes to MS morbidity or merely reflects an epiphenomenon.

scholarly journals MR imaging for the quantitative assessment of brain iron in aceruloplasminemia: a post-mortem validation study

NeuroImage ◽  
2021 ◽  
pp. 118752
Author(s):  
Lena H.P. Vroegindeweij ◽  
Piotr A. Wielopolski ◽  
Agnita J.W. Boon ◽  
J.H. Paul Wilson ◽  
Rob M. Verdijk ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Validation Study ◽  
Quantitative Assessment ◽  
Post Mortem ◽  
Brain Iron

Multiple Sclerosis and the Accumulation of Iron in the Basal Ganglia: Quantitative Assessment of Brain Iron Using MRI T2 Relaxometry

2010 ◽  
Vol 63 (3) ◽  
pp. 136-143 ◽  
Author(s):  
A. Burgetova ◽  
Z. Seidl ◽  
J. Krasensky ◽  
D. Horakova ◽  
M. Vaneckova
Keyword(s):  
Multiple Sclerosis ◽  
Basal Ganglia ◽  
Quantitative Assessment ◽  
Brain Iron

Author response for "Quantitative assessment of amygdala in macaca fascicularis monkeys"

2020 ◽  
Author(s):  
José‐Carlos Delgado‐González ◽  
Carlos‐de‐la Rosa Prieto ◽  
Nuria Vallejo‐Calcerrada ◽  
Diana‐Lucía Tarruela‐Hernández ◽  
Sandra Cebada‐Sánchez ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Macaca Fascicularis ◽  
Author Response

Initial experience with a new quantitative assessment tool for fluorescent imaging in peripheral artery disease

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Henrik Christian Rieß ◽  
Anna Duprée ◽  
Christian-Alexander Behrendt ◽  
Tilo Kölbel ◽  
Eike Sebastian Debus ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Quantitative Assessment ◽  
Tissue Perfusion ◽  
Fluorescent Imaging ◽  
Peripheral Artery ◽  
Peripheral Bypass ◽  
Before And After ◽  
Artery Disease ◽  
Green Fluorescent ◽  
Peripheral Bypass Grafting

Abstract. Background: Perioperative evaluation in peripheral artery disease (PAD) by common vascular diagnostic tools is limited by open wounds, medial calcinosis or an altered collateral supply of the foot. Indocyanine green fluorescent imaging (ICG-FI) has recently been introduced as an alternative tool, but so far a standardized quantitative assessment of tissue perfusion in vascular surgery has not been performed for this purpose. The aim of this feasibility study was to investigate a new software for quantitative assessment of tissue perfusion in patients with PAD using indocyanine green fluorescent imaging (ICG-FI) before and after peripheral bypass grafting. Patients and methods: Indocyanine green fluorescent imaging was performed in seven patients using the SPY Elite system before and after peripheral bypass grafting for PAD (Rutherford III-VI). Visual and quantitative evaluation of tissue perfusion was assessed in an area of low perfusion (ALP) and high perfusion (AHP), each by three independent investigators. Data assessment was performed offline using a specially customized software package (Institute for Laser Technology, University Ulm, GmbH). Slope of fluorescent intensity (SFI) was measured as time-intensity curves. Values were compared to ankle-brachial index (ABI), slope of oscillation (SOO), and time to peak (TTP) obtained from photoplethysmography (PPG). Results: All measurements before and after surgery were successfully performed, showing that ABI, TTP, and SOO increased significantly compared to preoperative values, all being statistically significant (P < 0.05), except for TTP (p = 0.061). Further, SFI increased significantly in both ALP and AHP (P < 0.05) and correlated considerably with ABI, TTP, and SOO (P < 0.05). Conclusions: In addition to ABI and slope of oscillation (SOO), the ICG-FI technique allows visual assessment in combination with quantitative assessment of tissue perfusion in patients with PAD. Ratios related to different perfusion patterns and SFI seem to be useful tools to reduce factors disturbing ICG-FI measurements.

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