Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

2021 ◽  
Author(s):  
Johannes Burtscher ◽  
Muhammed Muazzam Kamil Syed ◽  
Hilal A. Lashuel ◽  
Grégoire P. Millet
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

scholarly journals MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Jina Yun ◽  
Rajat Puri ◽  
Huan Yang ◽  
Michael A Lizzio ◽  
Chunlai Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Cortical Neurons ◽  
Therapeutic Strategies ◽  
Loss Of Function ◽  
Common Pathway ◽  
Mitochondrial Integrity ◽  
Promising Therapeutic Target ◽  
Mutant Phenotypes

Parkinson's disease (PD) genes PINK1 and parkin act in a common pathway that regulates mitochondrial integrity and quality. Identifying new suppressors of the pathway is important for finding new therapeutic strategies. In this study, we show that MUL1 suppresses PINK1 or parkin mutant phenotypes in Drosophila. The suppression is achieved through the ubiquitin-dependent degradation of Mitofusin, which itself causes PINK1/parkin mutant-like toxicity when overexpressed. We further show that removing MUL1 in PINK1 or parkin loss-of-function mutant aggravates phenotypes caused by loss of either gene alone, leading to lethality in flies and degeneration in mouse cortical neurons. Together, these observations show that MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin to maintain mitochondrial integrity. The MUL1 pathway compensates for loss of PINK1/parkin in both Drosophila and mammals and is a promising therapeutic target for PD.

Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease

2016 ◽  
Vol 22 (10) ◽  
pp. 1305-1311 ◽  
Author(s):  
Juan Camilo Jurado-Coronel ◽  
Marco Avila-Rodriguez ◽  
Francisco Capani ◽  
Janneth Gonzalez ◽  
Valentina Echeverria Moran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Therapeutic Target ◽  
Acetylcholine Receptors ◽  
Potential Therapeutic Target ◽  
Nicotinic Acetylcholine

scholarly journals Potassium Channels: A Potential Therapeutic Target for Parkinson’s Disease

2017 ◽  
Vol 34 (2) ◽  
pp. 341-348 ◽  
Author(s):  
Xiaoyan Chen ◽  
Bao Xue ◽  
Jun Wang ◽  
Haixia Liu ◽  
Limin Shi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Potassium Channels ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Ribosomal s15: A novel therapeutic target for Parkinson's disease

2014 ◽  
Vol 29 (8) ◽  
pp. 990-990
Author(s):  
Sheila M. Fleming ◽  
Alberto J. Espay
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic

Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?

2011 ◽  
pp. 353-369
Author(s):  
Giselle M. Petzinger ◽  
Beth E. Fisher ◽  
Garnik Akopian ◽  
Ruth Wood ◽  
John P. Walsh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Therapeutic Target
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