scholarly journals Toward optimization ofin vivosuper-resolution ultrasound imaging using size-selected microbubble contrast agents

2017 ◽  
Vol 44 (12) ◽  
pp. 6304-6313 ◽  
Author(s):  
Debabrata Ghosh ◽  
Fangyuan Xiong ◽  
Shashank R. Sirsi ◽  
Philip W. Shaul ◽  
Robert F. Mattrey ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Microbubble Contrast Agents

scholarly journals Doppler Slicing for Ultrasound Super-Resolution Without Contrast Agents

2021 ◽  
Author(s):  
Avinoam Bar-Zion ◽  
Oren Solomon ◽  
Claire Rabut ◽  
David Maresca ◽  
Yonina C. Eldar ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Super Resolution ◽  
Speckle Noise ◽  
Resolution Limit ◽  
Fourier Decomposition ◽  
Brain Scans ◽  
Microbubble Contrast Agents ◽  
Resolution Imaging ◽  
Vascular Structures

Much of the information needed for diagnosis and treatment monitoring of diseases like cancer and cardiovascular disease is found at scales below the resolution limit of classic ultrasound imaging. Recently introduced vascular super-localization methods provide more than a ten-fold improvement in spatial resolution by precisely estimating the positions of microbubble contrast agents. However, most vascular ultrasound scans are currently performed without contrast agents due to the associated cost, training, and post-scan monitoring. Here we show that super-resolution ultrasound imaging of dense vascular structures can be achieved using the natural contrast of flowing blood cells. Instead of relying on separable targets, we used Fourier-based decomposition to separate signals arising from the different scales of vascular structures while removing speckle noise using multi-ensemble processing. This approach enabled the use of compressed sensing for super-resolution imaging of the underlying vascular structures, improving resolution by a factor of four. Reconstruction of ultrafast mouse brain scans revealed details that could not be resolved in regular Doppler images, agreeing closely with bubble-based super-localization microscopy of the same fields of view. By combining multi-ensemble Doppler acquisitions with narrowband Fourier decomposition and computational super-resolution imaging, this approach opens new opportunities for affordable and scalable super-resolution ultrasound imaging.

scholarly journals Coherent Multi-Transducer Ultrasound Imaging with Microbubble Contrast Agents

2019 ◽  
Author(s):  
Kirsten Christensen-Jeffries ◽  
Laura Peralta ◽  
Michael Reinwald ◽  
Joseph V Hajnal ◽  
Robert J Eckersley
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Microbubble Contrast Agents

Template-based formation of ultrasound microbubble contrast agents

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69185-69190 ◽  
Author(s):  
Hsiu-Ying Huang ◽  
Cheng-An J. Lin ◽  
Walter H. Chang ◽  
Chih-Kuang Yeh
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Ultrasound Images ◽  
Medical Ultrasound ◽  
Medical Ultrasound Imaging ◽  
Microbubble Contrast Agents

Precisely controlling microbubble size is critical for medical ultrasound imaging, where large microbubble contrast agents may lead to pulmonary microvascular embolization. Here we introduced a method of preparing uniform microbubbles for ultrasound images.

scholarly journals EVALUATION OF IN-STENT NEOATHEROSCLEROSIS USING ADMINISTRATION OF MICROBUBBLE CONTRAST AGENTS DURING OPTICAL COHERENCE TOMOGRAPHY

2016 ◽  
Vol 67 (13) ◽  
pp. 272
Author(s):  
Norikiyo Oka ◽  
Hideki Kitahara ◽  
Takashi Nakayama ◽  
Yoshihide Fujimoto ◽  
Yoshio Kobayashi
Keyword(s):  
Optical Coherence Tomography ◽  
Contrast Agents ◽  
Optical Coherence ◽  
Microbubble Contrast Agents

Targeting and ultrasound imaging of microbubble-based contrast agents

1999 ◽  
Vol 8 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Alexander L. Klibanov ◽  
Michael S. Hughes ◽  
Flordeliza S. Villanueva ◽  
Ron J. Jankowski ◽  
William R. Wagner ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging

Techniques for perfusion imaging with microbubble contrast agents

2001 ◽  
Vol 48 (6) ◽  
pp. 1483-1494 ◽  
Author(s):  
D.H. Simpson ◽  
P.N. Burns ◽  
M.A. Averkiou
Keyword(s):  
Contrast Agents ◽  
Perfusion Imaging ◽  
Microbubble Contrast Agents
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