scholarly journals Motion compensation for aortic valves using partial angle CT reconstructions motion compensation of cardiac valve CT

2021 ◽  
Author(s):  
Sergej Lebedev ◽  
Eric Fournié ◽  
Joscha Maier ◽  
Karl Stierstorfer ◽  
Marc Kachelrieß
Keyword(s):  
Motion Compensation ◽  
Cardiac Valve ◽  
Aortic Valves

Abstract MP235: PROX1 Contributes To Cardiac Valve Disease

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
YenChun Ho ◽  
Xin Geng ◽  
Rohan Varshney ◽  
Jang Kim ◽  
Sandeep Surbrahmanian ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heart Valves ◽  
Cardiac Valve ◽  
Valve Disease ◽  
Matrix Composition ◽  
Cardiac Valves ◽  
Aortic Valves ◽  
Mitral Valves ◽  
Valve Development ◽  
Cardiac Valve Disease

Background: Heart valves regulate the unidirectional forward flow and prevent retrograde backflow of blood during the cardiac cycle. Cardiac valve disease (CVD) is observed in approximately 2.5% of the general population and the incidence increases to ~10% in elderly people. Patients with severe CVD require surgery and effective pharmacological treatments are currently not available. PROX1 is a transcription factor that regulates the development of lymphatic, venous, and lymphovenous valves (vascular valves). We identified that PROX1 is also expressed in a subset of valvular endothelial cells (VECs) that are located on the downstream (fibrosa) side of cardiac valves. Whether PROX1 regulates cardiac valve development and disease is not known. Method and Results: We have discovered that mice lacking Prox1 in their VECs ( Prox1 ΔVEC ) develop enlarged aortic and mitral valves in which the expression of proteoglycans is increased (control, N=10; Prox1 ΔVEC , N=9, p <0.05). Echocardiography revealed moderate to severe stenosis of aortic valves of Prox1 ΔVEC mice (control, N=5; Prox1 ΔVEC , N=9, p <0.05). PROX1 regulates the expression of the transcription factor FOXC2 in the vascular valves. Similarly, we have found that the expression of FOXC2 is downregulated in the VECs of Prox1 ΔVEC mice. Specific knockdown of FOXC2 in VECs results in the thickening of aortic valves (control, N=10; shFoxc2 ΔVEC , N=8, p <0.05). Furthermore, restoration of FOXC2 expression in VECs ( Foxc2 OE-VEC ) ameliorates the thickening of the aortic valves of Prox1 ΔVEC mice ( Prox1 ΔVEC , N=9; Foxc2 OE-VEC ; Prox1 ΔVEC , N=8, p <0.05). We have also determined that the expression of platelet-derived growth factor-B ( Pdgfb ) is increased in the valve tissue of Prox1 ΔVEC mice and in PROX1 deficient sheep mitral valve VECs (MVECs) (siCtrl , N=4; siProx1 , N=4, p <0.05). Additionally, hyperactivation of PDGF-B signaling in mice results in a phenotype that is similar to Prox1 ΔVEC mice (control , N=4; Pdgfb GOF , N=3, p <0.05). Conclusion: Together these data suggest that PROX1 maintains the extracellular matrix composition of cardiac valves by regulating the expressions of FOXC2 and PDGF-B in VECs.

Cardiac Valve Replacement with Heterologous Aortic Valves

1969 ◽  
Vol 39 (1) ◽  
pp. 59-65 ◽  
Author(s):  
J. P. Richardson ◽  
J. K. Clarebrough
Keyword(s):  
Valve Replacement ◽  
Cardiac Valve ◽  
Aortic Valves ◽  
Cardiac Valve Replacement

Prevalence of Mitral Valve Prolapse and Congenital Bicuspid Aortic Valves in Black and White Patients Undergoing Cardiac Valve Operations

2013 ◽  
Vol 111 (6) ◽  
pp. 898-901 ◽  
Author(s):  
Gian M. Novaro ◽  
Penny L. Houghtaling ◽  
A. Marc Gillinov ◽  
Eugene H. Blackstone ◽  
Craig R. Asher
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Cardiac Valve ◽  
Aortic Valves ◽  
Black And White ◽  
Bicuspid Aortic Valves ◽  
White Patients

An Assessment of Ca-Naphthenate-Epon Mixtures as Standards for Calcium Quantification in Aortic Valve Leaflets

1982 ◽  
Vol 40 ◽  
pp. 390-391
Author(s):  
Kathryn N. Colonna ◽  
Sydney S. Breese ◽  
Susan C. Sellers ◽  
J. David Deck
Keyword(s):  
Aortic Valve ◽  
Aortic Valves ◽  
X Ray ◽  
Aortic Valve Leaflets

Qualitative x-ray microanalytical studies used to demonstrate calcium in bioprosthetic aortic valves have shown that it occurs in a range of morphological forms. A consistent and reproducible standard for measuring calcium was necessary to investigate whether these forms represented varying concentrations of calcium. To provide such a standard, we tested a series of calcium naphthenate-epon mixtures.

On Transcatheter Aortic Valves

2011 ◽  
Vol 9 (6) ◽  
pp. 2
Author(s):  
SIDNEY GOLDSTEIN
Keyword(s):  
Aortic Valves

Minimally invasive aortic valve replacement (AVR) with sutureless valves compares well against conventional aortic valves

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
M Shrestha ◽  
S Sarikouch ◽  
Y Li ◽  
K Höffler ◽  
N Koigeldiyev ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Minimally Invasive ◽  
Valve Replacement ◽  
Aortic Valves

Minimally invasive versus conventional extracorporeal circulation in minimally invasive cardiac valve surgery

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
CJ Rustenbach ◽  
H Baumbach ◽  
JK Michaelsen ◽  
R Nagib ◽  
G Hipp ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Extracorporeal Circulation ◽  
Valve Surgery ◽  
Cardiac Valve ◽  
Cardiac Valve Surgery
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