NMR methods for studying the structure and dynamics of oncogenic and antihistaminic peptides in biomembranes

2004 ◽  
Vol 42 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Christina Sizun ◽  
Fabien Aussenac ◽  
Axelle Grelard ◽  
Erick J. Dufourc
Keyword(s):  
Structure And Dynamics ◽  
Nmr Methods

Structure and Dynamics of Bulk Polymers by NMR-Methods

1989 ◽  
Author(s):  
Vladimir D. Fedotov ◽  
Horst Schneider
Keyword(s):  
Structure And Dynamics ◽  
Bulk Polymers ◽  
Nmr Methods

31P-NMR Methods for Investigating Phospholipid-Based Molecular Structure and Dynamics

1993 ◽  
Vol 77 (1-4) ◽  
pp. 121-124 ◽  
Author(s):  
E. J. Dufourc ◽  
J.-C. Maillet ◽  
T. Pott ◽  
A. Leonard
Keyword(s):  
Molecular Structure ◽  
31P Nmr ◽  
Structure And Dynamics ◽  
Nmr Methods

scholarly journals Molecular chaperones and their denaturing effect on client proteins

2020 ◽  
Author(s):  
Sebastian Hiller
Keyword(s):  
Molecular Chaperone ◽  
Molecular Chaperones ◽  
Backbone Dynamics ◽  
Future Research ◽  
Chaperone Function ◽  
Structure And Dynamics ◽  
Client Proteins ◽  
Biophysical Techniques ◽  
Nmr Methods ◽  
Insight Into

Abstract Advanced NMR methods combined with biophysical techniques have recently provided unprecedented insight into structure and dynamics of molecular chaperones and their interaction with client proteins. These studies showed that several molecular chaperones are able to dissolve aggregation-prone polypeptides in aqueous solution. Furthermore, chaperone-bound clients often feature fluid-like backbone dynamics and chaperones have a denaturing effect on clients. Interestingly, these effects that chaperones have on client proteins resemble the effects of known chaotropic substances. Following this analogy, chaotropicity could be a fruitful concept to describe, quantify and rationalize molecular chaperone function. In addition, the observations raise the possibility that at least some molecular chaperones might share functional similarities with chaotropes. We discuss these concepts and outline future research in this direction.

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