Introduction. Classical amyotrophic lateral sclerosis (ALS) is not hard to diagnose, but when it comes to atypical forms of motor neuron disease (MND) which account for about 20% in clinical setting, we may face some difficulties in differentiating clearly between atypical forms of ALS/MND and other non-ALS diseases, such as multifocal motor neuropathy, chronic inflammatory demyelinating polyneuropathy and cervical spondylosis. Association between neuropathy and ALS has been reported rarely. Method. We report a patient who presented with clinical/electrophysiological features and investigations suggestive of chronic neuropathy but who later progressed with anterior horn and pyramidal signs and received a final diagnosis of ALS according to the original El Escorial criteria. Conclusion. Our findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include neuropathy among its non-motor features.
Increased muscle echointensity correlates with clinical disability and muscle strength in chronic inflammatory demyelinating polyneuropathy