Warranty costs: An age-dependent failure/repair model

2004 ◽  
Vol 51 (7) ◽  
pp. 959-976 ◽  
Author(s):  
Boyan Dimitrov ◽  
Stefanka Chukova ◽  
Zohel Khalil
Keyword(s):  
Age Dependent ◽  
Warranty Costs ◽  
Dependent Failure

scholarly journals OC-0052: Long-term age dependent failure pattern after BCT vs. mastectomy in low-risk breast cancer patients

2016 ◽  
Vol 119 ◽  
pp. S22
Author(s):  
T. Laurberg ◽  
C. Lyngholm ◽  
J. Alsner ◽  
P. Chritiansen ◽  
J. Overgaard
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Low Risk ◽  
Failure Pattern ◽  
Breast Cancer Patients ◽  
Age Dependent ◽  
Dependent Failure ◽  
Risk Breast Cancer

scholarly journals Pathways of cellular proteostasis in aging and disease

2017 ◽  
Vol 217 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Courtney L. Klaips ◽  
Gopal Gunanathan Jayaraj ◽  
F. Ulrich Hartl
Keyword(s):  
Protein Synthesis ◽  
Molecular Chaperones ◽  
Neurodegenerative Disorders ◽  
Cellular Protein ◽  
Protein Homeostasis ◽  
Precise Control ◽  
Parkinson’S Diseases ◽  
Age Dependent ◽  
Network Coordinates ◽  
Dependent Failure

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A complex and adaptive proteostasis network coordinates these processes with molecular chaperones of different classes and their regulators functioning as major players. This network serves to ensure that cells have the proteins they need while minimizing misfolding or aggregation events that are hallmarks of age-associated proteinopathies, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. It is now clear that the capacity of cells to maintain proteostasis undergoes a decline during aging, rendering the organism susceptible to these pathologies. Here we discuss the major proteostasis pathways in light of recent research suggesting that their age-dependent failure can both contribute to and result from disease. We consider different strategies to modulate proteostasis capacity, which may help develop urgently needed therapies for neurodegeneration and other age-dependent pathologies.

Sign in / Sign up

Export Citation Format

Share Document