scholarly journals Front Cover: Construction of the Pentacyclic Core and Formal Total Synthesis of (rac )-Renieramycin T (ChemistryOpen 10/2018)

ChemistryOpen ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 750-750
Author(s):  
Shinya Kimura ◽  
Naoki Saito
Keyword(s):  
Total Synthesis ◽  
Front Cover ◽  
Pentacyclic Core

Toward the total synthesis of citreamicin η: Synthesis of the pentacyclic core and GAB-ring annelation model studies

Tetrahedron ◽  
2018 ◽  
Vol 74 (38) ◽  
pp. 4981-4993 ◽  
Author(s):  
Shawn Blumberg ◽  
Stephen F. Martin
Keyword(s):  
Total Synthesis ◽  
Model Studies ◽  
Pentacyclic Core

scholarly journals Synthesis of (–)-Kopsifoline A and (+)-Kopsifoline E

2021 ◽  
Author(s):  
In-Soo Myeong ◽  
Nadide Hazal Avci ◽  
Mohammad Movassaghi
Keyword(s):  
Total Synthesis ◽  
Bond Formation ◽  
Mitsunobu Reaction ◽  
Reaction Conditions ◽  
Synthetic Strategy ◽  
F Ring ◽  
Pentacyclic Core

We report the first total synthesis of (–)-kopsifoline A and (+)-kopsifoline E. Our synthetic strategy features a biogenetically inspired regioselective C17-functionalization of a versatile intermediate containing the pentacyclic core of aspidosperma alkaloids. While this advance intermediate provides (–)-kopsifoline D via C3–C21 bond formation, regioselective C17-boronation of its indoline substructure prior to introduction of the F-ring enables access to (–)-kopsifoline A and (+)-kopsifoline E. The vinylogous urethane substructure of the key intermediate was critical in C17-boronation over a competing C7-boronation in related indole derived substrates. After oxidation of the C17–B bond to introduce the C17-ether, the C3–C21 bond of the targets is secured under the Mitsunobu reaction conditions with the vinylogous urethane as the nucleophilic component.

scholarly journals Synthetic Studies on Et-743. Assembly of the Pentacyclic Core and a Formal Total Synthesis

2008 ◽  
Vol 73 (24) ◽  
pp. 9594-9600 ◽  
Author(s):  
Dan Fishlock ◽  
Robert M. Williams
Keyword(s):  
Total Synthesis ◽  
Synthetic Studies ◽  
Pentacyclic Core

Total synthesis study of rauvomines A and B: construction of the pentacyclic core structure

2020 ◽  
Vol 7 (13) ◽  
pp. 1685-1689
Author(s):  
Binglu Wu ◽  
Zhi-Jiang Jiang ◽  
Jianbo Tang ◽  
Zhanghua Gao ◽  
Hongze Liang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Aldol Reaction ◽  
Core Structure ◽  
Mukaiyama Aldol Reaction ◽  
New Strategy ◽  
Mukaiyama Aldol ◽  
Pentacyclic Core

The fifth ring of rauvomines can be annulated via a Mukaiyama-Aldol reaction as a new strategy for sarpagine scaffold construction.

scholarly journals Front Cover: Total Synthesis of Dictyodendrins A–F by the Gold‐Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole (Chem. Eur. J. 49/2020)

2020 ◽  
Vol 26 (49) ◽  
pp. 11060-11060
Author(s):  
Junpei Matsuoka ◽  
Shinsuke Inuki ◽  
Yuka Matsuda ◽  
Yoichi Miyamoto ◽  
Mayumi Otani ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Front Cover ◽  
Cascade Cyclization

scholarly journals Front Cover: Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies (ChemMedChem 17/2019)

ChemMedChem ◽  
2019 ◽  
Vol 14 (17) ◽  
pp. 1573-1573
Author(s):  
Ruben Bartholomäus ◽  
Simon Nicolussi ◽  
Alice Baumann ◽  
Mark Rau ◽  
Ana Catarina Simão ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Front Cover ◽  
Uptake Inhibitor ◽  
Sar Studies

scholarly journals Construction of the Pentacyclic Core and Formal Total Synthesis of (rac )-Renieramycin T

ChemistryOpen ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 764-771 ◽  
Author(s):  
Shinya Kimura ◽  
Naoki Saito
Keyword(s):  
Total Synthesis ◽  
Pentacyclic Core

scholarly journals Front Cover: SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs (Chem. Eur. J. 66/2020)

2020 ◽  
Vol 26 (66) ◽  
pp. 15047-15047
Author(s):  
Paul R. Wosniok ◽  
Christopher Knopf ◽  
Sandra Dreisigacker ◽  
J. Manuel Orozco‐Rodriguez ◽  
Bettina Hinkelmann ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Front Cover ◽  
Sar Studies

Front Cover: Total Synthesis of Estradiol Methyl Ether and Its Five-Pot Synthesis with an Organocatalyst (Eur. J. Org. Chem. 41/2018)

2018 ◽  
Vol 2018 (41) ◽  
pp. 5615-5615
Author(s):  
Seitaro Koshino ◽  
Eunsang Kwon ◽  
Yujiro Hayashi
Keyword(s):  
Total Synthesis ◽  
Methyl Ether ◽  
Front Cover
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