Synthesis of Seleno Oxindoles via Iodine-induced Radical Cyclization of N-arylacrylamides with Diorganyl Diselenides

A mild radical cascade cyclization of N-arylacrylamides with diselenides for the preparation of oxindoles via iodine oxidation is disclosed, which provide an eco-friendly process for the construction of C–Se bond. 25 Examples of N-arylacrylamide substrates were investigated with excellent yields. Besides, the tandem cyclization of acrylamide with diphenyl disulfide was also applicable under the same condition.

Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas

Herein, we report a substrate-controlled cascade cyclization of o-alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis...

Total Syntheses of Seven Stemoamide-Type Stemona Alkaloids

Six Stemona alkaloids were synthesized racemically by using stemoamide, obtained via cascade cyclization or our reported transannular cyclization of parvistemoamide, as the common intermediate. Thioamides facilitated the separation of isosaxorumamide...