A 9‐year‐old male with Barth syndrome and cardiac transplant presenting with hyperviscosity syndrome caused by EBV‐negative plasmacytoid posttransplant lymphoproliferative disorder

We report a 15-year-old cardiac transplant recipient who developed a monomorphic posttransplant lymphoproliferative disorder (PTLPD) which demonstrated morphological and immunohistochemical features of anaplastic large cell lymphoma including CD30 and anaplastic lymphoma kinase (ALK) immunopositivity but lacking the commonly associated t(2;5) translocation. The neoplastic cells were Epstein-Barr Virus (EBV)-negative. T-cell PTLPD is an uncommon but recognized late complication in solid organ transplant recipients. This is the first reported case, to our knowledge, of PTLPD occurring in childhood with an ALK+, CD30+ anaplastic large cell lymphoma phenotype.

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Quantitative Oropharyngeal Epstein-Barr Virus Shedding in Renal and Cardiac Transplant Recipients: Relationship to Immunosuppressive Therapy, Serologic Responses, and the Risk of Posttransplant Lymphoproliferative Disorder

The Journal of Infectious Diseases ◽

10.1093/infdis/166.5.986 ◽

1992 ◽

Vol 166 (5) ◽

pp. 986-994 ◽

Cited By ~ 93

Author(s):

J. K. Preiksaitis ◽

F. Diaz-Mitoma ◽

F. Mirzayans ◽

S. Roberts ◽

D. L. J. Tyrrell

Keyword(s):

Immunosuppressive Therapy ◽

Lymphoproliferative Disorder ◽

Epstein Barr Virus ◽

Cardiac Transplant ◽

Transplant Recipients ◽

Posttransplant Lymphoproliferative Disorder ◽

Virus Shedding ◽

Barr Virus ◽

Epstein Barr

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Plasmacytic posttransplant lymphoproliferative disorder with hyperviscosity syndrome in a child after liver transplant

Hepatology ◽

10.1002/hep.28657 ◽

2016 ◽

Vol 64 (6) ◽

pp. 2250-2252

Author(s):

Christine H. Yang ◽

Saurabh Gombar ◽

Clare J. Twist ◽

Dita Gratzinger ◽

Carlos O. Esquivel ◽

...

Keyword(s):

Liver Transplant ◽

Lymphoproliferative Disorder ◽

Posttransplant Lymphoproliferative Disorder ◽

Hyperviscosity Syndrome

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Ileocolic and Jejunal Intussusceptions Requiring Surgical Intervention in a Pediatric Patient with Posttransplant Lymphoproliferative Disorder

The American Surgeon ◽

10.1177/000313481608200939 ◽

2016 ◽

Vol 82 (9) ◽

pp. 792-793

Author(s):

Ilan Maizlin ◽

David A. Klima ◽

Elizabeth A. Beierle

Keyword(s):

Case Report ◽

Pediatric Patient ◽

Lymphoproliferative Disorder ◽

Surgical Intervention ◽

Lymphoid Hyperplasia ◽

Cardiac Transplant ◽

Posttransplant Lymphoproliferative Disorder ◽

Intestinal Intussusception ◽

Transplant Patients

Posttransplant lymphoproliferative disorder (PTLD) is not uncommon in pediatrics. This case report describes a case of intestinal intussusception that occurred secondary to lymphoid hyperplasia in a child with PTLD following a cardiac transplant. This case was unique in its presentation with multiple areas of intussusception and with need for surgical intervention. The diagnosis of intussusception secondary to lead points from PTLD should be strongly considered in pediatric transplant patients presenting with abdominal complaints.

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