Measures of ventilation heterogeneity mapped with hyperpolarized helium‐3 MRI demonstrate a T2‐high phenotype in asthma

2021 ◽  
Author(s):  
W. Gerald Teague ◽  
Jaime Mata ◽  
Kun Qing ◽  
Nicholas J. Tustison ◽  
John P. Mugler ◽  
...  
Keyword(s):  
Hyperpolarized Helium ◽  
Ventilation Heterogeneity ◽  
Helium 3

Airway closure is the predominant physiological mechanism of low ventilation seen on hyperpolarized helium-3 MRI lung scans

2020 ◽  
Author(s):  
Kris Nilsen ◽  
Bruce R. Thompson ◽  
Natalie Zajakovski ◽  
Michael Kean ◽  
Benjamin E. Harris ◽  
...  
Keyword(s):  
Physiological Mechanism ◽  
Forced Oscillation Technique ◽  
Physiological Measures ◽  
Airway Closure ◽  
Methacholine Challenge ◽  
Hyperpolarized Helium ◽  
Variate Analysis ◽  
Ventilation Heterogeneity ◽  
Mri Scans ◽  
Helium 3

Hyperpolarized helium-3 MRI (3He MRI) provides detailed visualization of low- (hypo- and non-) ventilated lung. Physiological measures of gas mixing may be assessed by multiple breath nitrogen washout (MBNW) and of airway closure by forced oscillation technique (FOT). We hypothesize that in patients with asthma, areas of low-ventilated lung on 3He MRI are the result of airway closure. Ten control subjects, ten asthma subjects with normal spirometry (non-obstructed), and ten asthmatic subjects with reduced baseline lung function (obstructed) attended two testing sessions. On visit one, baseline plethysmography was performed followed by spirometry, MBNW and FOT assessment pre- and post-methacholine challenge. On visit two, 3He MRI scans were conducted pre- and post-methacholine challenge. Post methacholine the volume of low ventilated lung increased from 8.3% to 13.8% in the non-obstructed group (p = 0.012) and from 13.0% to 23.1% in the obstructed group (p=0.001). In all groups, the volume of low ventilation from 3He MRI correlated with a marker of airway closure in obstructive subjects, Xrs (6Hz) and the marker of ventilation heterogeneity Scond with r2 values of 0.61 and 0.56 respectively. The change in Xrs (6Hz) correlated well (r2 = 0.45), while the change in Scond was largely independent of, the change in low ventilation volume (r2=0.13). The only significant predictor of low ventilation volume from the multi-variate analysis was Xrs (6Hz). This is consistent with the concept that regions of poor or absent ventilation seen on 3He MRI are primarily the result of airway closure.

scholarly journals Measures of Ventilation Heterogeneity Mapped with Hyperpolarized Helium-3 (HHe-3) MRI Demonstrate a T2-High Phenotype in Asthma

2020 ◽  
Author(s):  
William Teague ◽  
Jaime Mata ◽  
Kun Qing ◽  
Nicholas Tustison ◽  
John Mugler ◽  
...  
Keyword(s):  
Hyperpolarized Helium ◽  
Ventilation Heterogeneity ◽  
Helium 3

Measurement of Large Airways Using Dynamic 3D Hyperpolarized Helium-3 MR Imaging.

2009 ◽  
Author(s):  
ET Peterson ◽  
JH Holmes ◽  
A Dattawadkar ◽  
G Agrawal ◽  
J Dai ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hyperpolarized Helium ◽  
Large Airways ◽  
Helium 3

Measurement of Pulmonary Partial Pressure of Oxygen and Oxygen Depletion Rate with Hyperpolarized Helium-3 MRI: A Preliminary Reproducibility Study on Pig Model

2008 ◽  
Vol 15 (6) ◽  
pp. 702-712 ◽  
Author(s):  
Jiangsheng Yu ◽  
Sheeva Rajaei ◽  
Masaru Ishii ◽  
Michelle Law ◽  
Kiarash Emami ◽  
...  
Keyword(s):  
Partial Pressure ◽  
Oxygen Depletion ◽  
Pig Model ◽  
Partial Pressure Of Oxygen ◽  
Hyperpolarized Helium ◽  
Reproducibility Study ◽  
Depletion Rate ◽  
Helium 3

scholarly journals Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion During Breathing

2009 ◽  
Vol 75 (1) ◽  
pp. 276-284 ◽  
Author(s):  
Jing Cai ◽  
Ke Sheng ◽  
Stanley H. Benedict ◽  
Paul W. Read ◽  
James M. Larner ◽  
...  
Keyword(s):  
Dynamic Mri ◽  
Hyperpolarized Helium ◽  
Lung Motion ◽  
Helium 3

scholarly journals Feature analysis of hyperpolarized helium-3 pulmonary MRI: A study of asthmatics versus nonasthmatics

2010 ◽  
Vol 63 (6) ◽  
pp. 1448-1455 ◽  
Author(s):  
Nicholas J. Tustison ◽  
Talissa A. Altes ◽  
Gang Song ◽  
Eduard E. de Lange ◽  
John P. Mugler ◽  
...  
Keyword(s):  
Feature Analysis ◽  
Hyperpolarized Helium ◽  
Helium 3

scholarly journals Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI

2010 ◽  
Vol 32 (6) ◽  
pp. 1379-1387 ◽  
Author(s):  
Ravi Aysola ◽  
Eduard E. de Lange ◽  
Mario Castro ◽  
Talissa A. Altes
Keyword(s):  
Heterogeneous Distribution ◽  
Hyperpolarized Helium ◽  
Helium 3
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