Horse liver alcohol dehydrogenase (HLADH); biocatalytic redox-transformations in organic synthesis

1997 ◽  
Vol 339 (1) ◽  
pp. 754-757 ◽  
Author(s):  
Christian Hertweck ◽  
Wilhelm Boland
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Redox Transformations ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver

Enzymes in organic synthesis. 32. Stereospecific horse liver alcohol dehydrogenase-catalyzed oxidations of exo- and endo-oxabicyclic meso diols

1984 ◽  
Vol 62 (11) ◽  
pp. 2578-2582 ◽  
Author(s):  
J. Bryan Jones ◽  
Christopher J. Francis
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Preparative Scale ◽  
Enantiomerically Pure ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver ◽  
One Step ◽  
Catalyzed Oxidation ◽  
Enzymes In Organic Synthesis

Preparative-scale horse liver alcohol dehydrogenase-catalyzed oxidation of mesoexo- and endo-7-oxabicyclo[2.2.1]heptane diols provides a direct one-step route to enantiomerically pure chiral γ-lactones of the oxabicyclic series.

Enzymes in organic synthesis. 23. Effects of organic solvents on horse liver alcohol dehydrogenase-catalyzed oxidation

1982 ◽  
Vol 60 (8) ◽  
pp. 1030-1033 ◽  
Author(s):  
J. Bryan Jones ◽  
Harold M. Schwartz
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Organic Solvents ◽  
Butyl Alcohol ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Liver Alcohol Dehydrogenase ◽  
Tert Butyl Alcohol ◽  
Horse Liver ◽  
Catalyzed Oxidation ◽  
Enzymes In Organic Synthesis

The effects have been evaluated of up to 50% (v/v) of methanol, tert-butyl alcohol, dimethylsulfoxide, sulfolane, acetonitrile, dimethylformamide, N-methyl-2-pyrrolidone, hexamethylphosphoramide, acetone, 2-butanone, tetrahydrofuran, dimethoxyethane, diglyme, and dioxane on horse liver alcohol dehydrogenase (HLADH)-catalyzed oxidation of the representative alcohol substrate cyclohexanol. With the exception of dimethylsulfoxide and dimethylformamide, all solvents tested are suitable for use as cosolvents with HLADH in the oxidative and reductive directions.

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