scholarly journals Evidence for the preferential reuse of sub‐domain motifs in primordial protein folds

Author(s):  
Leonhard Heizinger ◽  
Rainer Merkl
Keyword(s):  

2016 ◽  
Vol 13 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Dapeng Li ◽  
Ying Ju ◽  
Quan Zou
Keyword(s):  


2015 ◽  
Vol 37 (4) ◽  
pp. 426-436 ◽  
Author(s):  
Ngaam J. Cheung ◽  
Xue-Ming Ding ◽  
Hong-Bin Shen


2013 ◽  
Vol 110 (15) ◽  
pp. 5744-5745 ◽  
Author(s):  
R. B. Best
Keyword(s):  


2013 ◽  
Vol 43 (9) ◽  
pp. 1182-1191 ◽  
Author(s):  
Elham Abbasi ◽  
Mehdi Ghatee ◽  
M.E. Shiri
Keyword(s):  


2001 ◽  
Vol 45 (S5) ◽  
pp. 127-132 ◽  
Author(s):  
David T. Jones
Keyword(s):  


2001 ◽  
Vol 10 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Richard R. Copley ◽  
Robert B. Russell ◽  
Chris P. Ponting
Keyword(s):  


Structure ◽  
1998 ◽  
Vol 6 (7) ◽  
pp. 875-884 ◽  
Author(s):  
Andrew CR Martin ◽  
Christine A Orengo ◽  
E Gail Hutchinson ◽  
Susan Jones ◽  
Maria Karmirantzou ◽  
...  
Keyword(s):  


2009 ◽  
Vol 07 (05) ◽  
pp. 773-788 ◽  
Author(s):  
PENG CHEN ◽  
CHUNMEI LIU ◽  
LEGAND BURGE ◽  
MOHAMMAD MAHMOOD ◽  
WILLIAM SOUTHERLAND ◽  
...  

Protein fold classification is a key step to predicting protein tertiary structures. This paper proposes a novel approach based on genetic algorithms and feature selection to classifying protein folds. Our dataset is divided into a training dataset and a test dataset. Each individual for the genetic algorithms represents a selection function of the feature vectors of the training dataset. A support vector machine is applied to each individual to evaluate the fitness value (fold classification rate) of each individual. The aim of the genetic algorithms is to search for the best individual that produces the highest fold classification rate. The best individual is then applied to the feature vectors of the test dataset and a support vector machine is built to classify protein folds based on selected features. Our experimental results on Ding and Dubchak's benchmark dataset of 27-class folds show that our approach achieves an accuracy of 71.28%, which outperforms current state-of-the-art protein fold predictors.



1996 ◽  
Vol 264 (3) ◽  
pp. 603-623 ◽  
Author(s):  
Paul M. Harrison ◽  
Michael J.E. Sternberg
Keyword(s):  


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