Evaluation and performance of desorption electrospray ionization using a triple quadrupole mass spectrometer for quantitation of pharmaceuticals in plasma

2010 ◽  
Vol 24 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Joseph H. Kennedy ◽  
Justin M. Wiseman
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Desorption Electrospray Ionization ◽  
Quadrupole Mass Spectrometer ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
And Performance

Characterization and Performance of MALDI on a Triple Quadrupole Mass Spectrometer for Analysis and Quantification of Small Molecules

2005 ◽  
Vol 77 (17) ◽  
pp. 5643-5654 ◽  
Author(s):  
Jason Gobey ◽  
Mark Cole ◽  
John Janiszewski ◽  
Thomas Covey ◽  
Tung Chau ◽  
...  
Keyword(s):  
Small Molecules ◽  
Mass Spectrometer ◽  
Quadrupole Mass Spectrometer ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
And Performance

scholarly journals Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS3of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ali S. Abdelhameed ◽  
Adnan A. Kadi ◽  
Hatem A. Abdel-Aziz ◽  
Rihab F. Angawi ◽  
Mohamed W. Attwa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometer ◽  
Ion Trap ◽  
Quadrupole Mass Spectrometer ◽  
Ion Trap Mass Spectrometry ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
Fragment Ions ◽  
Mass Spectrometry System

A new approach was recently introduced to improve the structure elucidation power of tandem mass spectrometry simulating the MS3of ion trap mass spectrometry system overcoming the different drawbacks of the latter. The fact that collision induced dissociation in the triple quadrupole mass spectrometer system provides richer fragment ions compared to those achieved in the ion trap mass spectrometer system utilizing resonance excitation. Moreover, extracting comprehensive spectra in the ion trap needs multistage fragmentation, whereas similar fragment ions may be acquired from one stage product ion scan using the triple quadrupole mass spectrometer. The new strategy was proven to enhance the qualitative performance of tandem mass spectrometry for structural elucidation of different chemical entities. In the current study we are endeavoring to prove our hypothesis of the efficiency of the new pseudo-MS3technique via its comparison with the MS3mode of ion trap mass spectrometry system. Ten pharmacologically and synthetically important (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones4a–j) were chosen as model compounds for this study. This strategy permitted rigorous identification of all fragment ions using triple quadrupole mass spectrometer with sufficient specificity. It can be used to elucidate structures of different unknown components. The data presented in this paper provide clear evidence that our new pseudo-MS3may simulate the MS3of ion trap spectrometry system.

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