Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs

2012 ◽  
Vol 26 (5) ◽  
pp. 499-509 ◽  
Author(s):  
Hugues Henry ◽  
Hamid Reza Sobhi ◽  
Olaf Scheibner ◽  
Maciej Bromirski ◽  
Subodh B. Nimkar ◽  
...  
Keyword(s):  
High Resolution ◽  
Mass Spectrometer ◽  
Single Stage ◽  
Quadrupole Mass Spectrometer ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
Quantitative Analyses ◽  
Resolution Single

scholarly journals Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS3of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ali S. Abdelhameed ◽  
Adnan A. Kadi ◽  
Hatem A. Abdel-Aziz ◽  
Rihab F. Angawi ◽  
Mohamed W. Attwa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometer ◽  
Ion Trap ◽  
Quadrupole Mass Spectrometer ◽  
Ion Trap Mass Spectrometry ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
Fragment Ions ◽  
Mass Spectrometry System

A new approach was recently introduced to improve the structure elucidation power of tandem mass spectrometry simulating the MS3of ion trap mass spectrometry system overcoming the different drawbacks of the latter. The fact that collision induced dissociation in the triple quadrupole mass spectrometer system provides richer fragment ions compared to those achieved in the ion trap mass spectrometer system utilizing resonance excitation. Moreover, extracting comprehensive spectra in the ion trap needs multistage fragmentation, whereas similar fragment ions may be acquired from one stage product ion scan using the triple quadrupole mass spectrometer. The new strategy was proven to enhance the qualitative performance of tandem mass spectrometry for structural elucidation of different chemical entities. In the current study we are endeavoring to prove our hypothesis of the efficiency of the new pseudo-MS3technique via its comparison with the MS3mode of ion trap mass spectrometry system. Ten pharmacologically and synthetically important (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones4a–j) were chosen as model compounds for this study. This strategy permitted rigorous identification of all fragment ions using triple quadrupole mass spectrometer with sufficient specificity. It can be used to elucidate structures of different unknown components. The data presented in this paper provide clear evidence that our new pseudo-MS3may simulate the MS3of ion trap spectrometry system.

Sequence analysis of polypeptides by collision activated dissociation on a triple quadrupole mass spectrometer

1981 ◽  
Vol 8 (9) ◽  
pp. 397-408 ◽  
Author(s):  
Donald F. Hunt ◽  
Alexander M. Buko ◽  
John M. Ballard ◽  
Jeffrey Shabanowitz ◽  
Anne B. Giordani
Keyword(s):  
Sequence Analysis ◽  
Mass Spectrometer ◽  
Quadrupole Mass Spectrometer ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer
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