Electron capture dissociation of polypeptides using a 3 Tesla Fourier transform ion cyclotron resonance mass spectrometer

2002 ◽  
Vol 16 (10) ◽  
pp. 936-943 ◽  
Author(s):  
Nicolas C. Polfer ◽  
Kim F. Haselmann ◽  
Roman A. Zubarev ◽  
Pat R. R. Langridge-Smith
Keyword(s):  
Fourier Transform ◽  
Electron Capture ◽  
Mass Spectrometer ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
3 Tesla ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron

scholarly journals Electron Capture Dissociation Implementation Progress in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2008 ◽  
Vol 19 (6) ◽  
pp. 762-771 ◽  
Author(s):  
Yury O. Tsybin ◽  
John P. Quinn ◽  
Oleg Yu Tsybin ◽  
Christopher L. Hendrickson ◽  
Alan G. Marshall
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron ◽  
Implementation Progress

scholarly journals Determination of AberrantO-Glycosylation in the IgA1 Hinge Region by Electron Capture Dissociation Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry

2005 ◽  
Vol 280 (19) ◽  
pp. 19136-19145 ◽  
Author(s):  
Matthew B. Renfrow ◽  
Helen J. Cooper ◽  
Milan Tomana ◽  
Rose Kulhavy ◽  
Yoshiyuki Hiki ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Hinge Region ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron

Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry

2013 ◽  
Vol 85 (9) ◽  
pp. 4239-4246 ◽  
Author(s):  
Yuan Mao ◽  
Santosh G. Valeja ◽  
Jason C. Rouse ◽  
Christopher L. Hendrickson ◽  
Alan G. Marshall
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Fourier Transform ◽  
Structural Analysis ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Top Down ◽  
Ion Cyclotron

scholarly journals Evaluation and optimization of electron capture dissociation efficiency in fourier transform ion cyclotron resonance mass spectrometry

2005 ◽  
Vol 16 (7) ◽  
pp. 1060-1066 ◽  
Author(s):  
Melinda A. McFarland ◽  
Michael J. Chalmers ◽  
John P. Quinn ◽  
Christopher L. Hendrickson ◽  
Alan G. Marshall
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Dissociation Efficiency ◽  
Ion Cyclotron

scholarly journals Peptide and protein characterization by high-rate electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry

2004 ◽  
Vol 39 (7) ◽  
pp. 719-729 ◽  
Author(s):  
Youri O. Tsybin ◽  
Margareta Ramström ◽  
Matthias Witt ◽  
Gökhan Baykut ◽  
Per Håkansson
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Protein Characterization ◽  
High Rate ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron

Hydrogen Atom Loss in Electron-Capture Dissociation: A Fourier Transform-Ion Cyclotron Resonance Study with Single Isotopomeric Ubiquitin Ions

2002 ◽  
Vol 8 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Kathrin Breuker ◽  
HanBin Oh ◽  
Blas A. Cerda ◽  
David M. Horn ◽  
Fred W. McLafferty
Keyword(s):  
Fourier Transform ◽  
Hydrogen Atom ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Reaction Pathway ◽  
Carbonyl Oxygen ◽  
Major Product ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron

In electron-capture dissociation (ECD), a multiply-protonated protein ion, trapped in a Fourier transform-ion cyclotron resonance (FT-ICR) cell, captures a low-energy electron at a protonated site. In a major reaction pathway, the resulting hydrogen atom attacks a backbone carbonyl oxygen to form a hypervalent species that immediately dissociates into a complementary c, z• ion pair. For larger proteins, the reduced odd-electron ion (M + nH)( n −1)+• is a major product, as shown here using isotopically isolated precursors. In addition, a hydrogen atom can be lost without further reaction, yielding the [M + ( n −1)H]( n −1)+ even-electron ions. The large effect of charge state on the yield of these ions suggests that the 9+ to 11+ charge states have novel charge-solvated secondary structures.

scholarly journals Erratum to: An antibiotic linked to peptides and proteins is released by electron capture dissociation fourier transform ion cyclotron resonance mass spectrometry

2003 ◽  
Vol 14 (6) ◽  
pp. 682-682 ◽  
Author(s):  
Clifton K. Fagerquist ◽  
Robert R. Hudgins ◽  
Mark R. Emmett ◽  
Kristina Håkansson ◽  
Alan G. Marshall
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron
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