Power analysis for stepped wedge trials with multiple interventions

2022 ◽  
Author(s):  
Phillip Sundin ◽  
Catherine M. Crespi
Keyword(s):  
Power Analysis ◽  
Stepped Wedge ◽  
Stepped Wedge Trials ◽  
Multiple Interventions

scholarly journals Analysis of cluster randomised stepped wedge trials with repeated cross-sectional samples

Trials ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Karla Hemming ◽  
Monica Taljaard ◽  
Andrew Forbes
Keyword(s):  
Stepped Wedge ◽  
Cross Sectional ◽  
Cluster Randomised ◽  
Stepped Wedge Trials

scholarly journals Health Economic Evaluation Alongside Stepped Wedge Trials: A Methodological Systematic Review

2020 ◽  
Vol 39 (1) ◽  
pp. 63-80 ◽  
Author(s):  
Thomas Lung ◽  
Lei Si ◽  
Richard Hooper ◽  
Gian Luca Di Tanna
Keyword(s):  
Systematic Review ◽  
Health Economic ◽  
Economic Evaluation ◽  
Health Economic Evaluation ◽  
Stepped Wedge ◽  
Stepped Wedge Trials

scholarly journals The hunt for efficient, incomplete designs for stepped wedge trials with continuous recruitment and continuous outcome measures

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Richard Hooper ◽  
Jessica Kasza ◽  
Andrew Forbes
Keyword(s):  
Outcome Measures ◽  
Total Sample ◽  
Fixed Number ◽  
Good Precision ◽  
Efficient Design ◽  
Stepped Wedge ◽  
Continuous Outcome ◽  
Incomplete Designs ◽  
Before And After ◽  
Stepped Wedge Trials

Abstract Background We consider the design of stepped wedge trials with continuous recruitment and continuous outcome measures. Suppose we recruit from a fixed number of clusters where eligible participants present continuously, and suppose we have fine control over when each cluster crosses to the intervention. Suppose also that we want to minimise the number of participants, leading us to consider “incomplete” designs (i.e. without full recruitment). How can we schedule recruitment and cross-over at different clusters to recruit efficiently while achieving good precision? Methods The large number of possible designs can make exhaustive searches impractical. Instead we consider an algorithm using iterative improvements to hunt for an efficient design. At each iteration (starting from a complete design) a single participant – the one with the smallest impact on precision – is removed, and small changes preserving total sample size are made until no further improvement in precision can be found. Results Striking patterns emerge. Solutions typically focus recruitment and cross-over on the leading diagonal of the cluster-by-time diagram, but in some scenarios clusters form distinct phases resembling before-and-after designs. Conclusions There is much to be learned about optimal design for incomplete stepped wedge trials. Algorithmic searches could offer a practical approach to trial design in complex settings generally.

scholarly journals Proposed variations of the stepped-wedge design can be used to accommodate multiple interventions

2017 ◽  
Vol 86 ◽  
pp. 160-167 ◽  
Author(s):  
Vivian H. Lyons ◽  
Lingyu Li ◽  
James P. Hughes ◽  
Ali Rowhani-Rahbar
Keyword(s):  
Stepped Wedge ◽  
Stepped Wedge Design ◽  
Multiple Interventions

scholarly journals Current issues in the design and analysis of stepped wedge trials

2015 ◽  
Vol 45 ◽  
pp. 55-60 ◽  
Author(s):  
James P. Hughes ◽  
Tanya S. Granston ◽  
Patrick J. Heagerty
Keyword(s):  
Stepped Wedge ◽  
Stepped Wedge Trials

scholarly journals The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs

2017 ◽  
Vol 14 (6) ◽  
pp. 639-647 ◽  
Author(s):  
Jennifer A Thompson ◽  
Katherine Fielding ◽  
James Hargreaves ◽  
Andrew Copas
Keyword(s):  
Optimal Design ◽  
Stepped Wedge ◽  
Stepped Wedge Trials
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